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Lymphocyte development must be tightly regulated in utero to prevent rejection. New work shows that the zinc finger protein Zfp608 negatively regulates the expression of recombination-activating genes 1 and 2 and may suppress fetal T cell development.
New data show that integrin signaling by the Syk tyrosine kinase requires adaptors, such as DAP12, that have immunoreceptor tyrosine-based activation motifs.
Fever is a beneficial systemic response to infection. Such a thermal increase triggers enhanced lymph node recruitment of lymphocytes by augmenting high endothelial venule expression of the homing molecules ICAM-1 and CCL21.
Emil R. Unanue recounts his seminal work 25 years ago demonstrating that antigens are phagocytosed and processed by antigen-presenting cells and that class II major histocompatibility complex molecules are peptide-binding proteins.