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The recent meeting on “Immune Correlates of Protection from HIV Infection and Disease” examined new data from a variety of preclinical and clinical settings. These new insights may facilitate vaccine design and clinical evaluation.
Contacts between T cell receptors and peptide–major histocompatibility complex molecules require specific amino acid interactions. However, some amino acids have no direct involvement in contact but nevertheless are critical for specificity.
How individual hematopoietic stem cells contribute to blood cell formation throughout a lifetime has remained a subject of debate. A new analysis suggests there is substantial variation in hematopoietic stem cell fate and self-renewal activity.
A pathway has been defined linking cell cycle inhibitor p27Kip1 to the inhibition of cyclin-dependent kinase 2 and its phosphorylation of transcription factor Smad3 in the induction of in vivo tolerance.