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The unpredictable stem cell

How individual hematopoietic stem cells contribute to blood cell formation throughout a lifetime has remained a subject of debate. A new analysis suggests there is substantial variation in hematopoietic stem cell fate and self-renewal activity.

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Figure 1: Competing models of HSC activation.

Kim Caesar

References

  1. Till, J.E. & McCulloch, E.A. Radiat. Res. 18, 96–105 (1963).

    Article  CAS  Google Scholar 

  2. Civin, C.I. et al. J. Immunol. 133, 157–165 (1984).

    CAS  PubMed  Google Scholar 

  3. Spangrude, G.J., Heimfeld, S. & Weissman, I.L. Science 241, 58–62 (1988).

    Article  CAS  Google Scholar 

  4. Terstappen, L.W., Huang, S., Safford, M., Lansdorp, P.M. & Loken, M.R. Blood 77, 1218–1227 (1991).

    CAS  PubMed  Google Scholar 

  5. Conneally, E., Cashman, J., Petzer, A. & Eaves, C. Proc. Natl. Acad. Sci. USA 94, 9836–9841 (1997).

    Article  CAS  Google Scholar 

  6. Gan, O.I., Murdoch, B., Larochelle, A. & Dick, J.E. Blood 90, 641–650 (1997).

    CAS  PubMed  Google Scholar 

  7. McKenzie, J.L., Gan, O.I., Doeden, M., Wang, J.C.Y. & Dick, J.E. Nat. Immunol. 7, 1225–1233 (2006).

    Article  CAS  Google Scholar 

  8. Jordan, C.T. & Lemischka, I.R. Genes Dev. 4, 220–223 (1990).

    Article  CAS  Google Scholar 

  9. Abkowitz, J.L. et al. Proc. Natl. Acad. Sci. USA 92, 2031–2035 (1995).

    Article  CAS  Google Scholar 

  10. Hao, Q.L., Shah, A.J., Thiemann, F.T., Smogorzewska, E.M. & Crooks, G.M. Blood 86, 3745–3753 (1995).

    CAS  PubMed  Google Scholar 

  11. Morrison, S. & Weissman, I.L. Immunity 1, 661–673 (1994).

    Article  CAS  Google Scholar 

  12. Ott, M.G. et al. Nat. Med. 12, 401–409 (2006).

    Article  CAS  Google Scholar 

  13. Kustikova, O. et al. Science 308, 1171–1174 (2005).

    Article  CAS  Google Scholar 

  14. Schmidt, M. et al. Nat. Med. 9, 463–468 (2003).

    Article  CAS  Google Scholar 

  15. Park, I.K. et al. Nature 423, 302–305 (2003).

    Article  CAS  Google Scholar 

Download references

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Crooks, G., Weinberg, K. The unpredictable stem cell. Nat Immunol 7, 1129–1130 (2006). https://doi.org/10.1038/ni1106-1129

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