The recent emergence of signaling roles for transition metals presages a broader contribution of these elements beyond their traditional functions as metabolic cofactors. New chemical approaches to identify the sources, targets and physiologies of transition-metal signaling can help expand understanding of the periodic table in a biological context.
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Acknowledgements
I thank the Howard Hughes Medical Institute as well as the US National Institutes of Health (grant GM 79465) for generous research support of my interests in the study of metals at the chemistry-biology interface. I thank A. Aron for helpful feedback on an earlier draft of this article.
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Chang, C. Searching for harmony in transition-metal signaling. Nat Chem Biol 11, 744–747 (2015). https://doi.org/10.1038/nchembio.1913
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DOI: https://doi.org/10.1038/nchembio.1913
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