An integrative approach has now enabled elucidation of the complete biosynthetic pathway of a prominent saponin adjuvant. Reconstruction of the whole biosynthetic pathway in a heterologous host provides new perspectives for the biotechnological supply of this immunostimulant.
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Courdavault, V., Papon, N. Accessing natural vaccine adjuvants. Nat Chem Biol 20, 401–403 (2024). https://doi.org/10.1038/s41589-024-01585-6
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DOI: https://doi.org/10.1038/s41589-024-01585-6