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Volume 7 Issue 4, April 2005

The Arabidopsis formin mutant athfh5-2 shows defects in cellularization. The image is false coloured, highlighting cellularization in yellow and dividing nuclei in blue.

Volume 7 Issue 4

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Editorial

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Correspondence

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News & Views

  • All members of the conserved family of structural maintenance of chromosomes (SMC) proteins are essential for cellular viability. The Smc1–Smc3 heterodimer is a constituent of cohesin and Smc2–Smc4 of condensin, which are both required for proper chromosome distribution at mitosis. Now, the third SMC heterodimer, Smc5–Smc6, which had previously been implicated only in DNA repair, also turns out to be crucial for chromosome segregation.

    • Yoshinori Watanabe
    News & Views

  • Monoubiquitination of the Fanconi anaemia protein FANCD2 is essential for its activity in DNA repair and tumour suppression. The recent identification of a specific de-ubiquitinating (DUB) enzyme for FANCD2 raises intriguing questions about how and why this tumour suppressor becomes deactivated.

    • Ashok R. Venkitaraman
    News & Views

  • Many biological processes require the movement of cells in response to guidance cues. Small GTPases and phosphoinositides are key mediators of the underlying cytoskeletal rearrangements, and a new study establishes that the localization and activation of the phosphoinositide phosphatase PTEN at the rear of chemotaxing neutrophils is mediated by the small GTPase RhoA.

    • Ruedi Meili
    • Atsuo T. Sasaki
    • Richard A. Firtel
    News & Views

  • How cells establish and maintain polarity during directed cell migration remains poorly understood. Nishiya et al. now describe an integrin signalling complex that includes paxillin and GIT1, which limits activation of Rac to the leading edge of a migrating cell.

    • Anna Huttenlocher
    News & Views

  • Epidermal growth factor and nerve growth factor (NGF) lead to significantly different temporal patterns of extracellular-signal-regulated kinase activation, and differential regulation of Ras and Rap1 have been implicated in mediating this temporal specificity. Now Sasagawa et al. derive a computational model that incorporates the known signalling interactions and identifies key points of regulation that control these processes.

    • Philip J. S. Stork
    News & Views
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