Epidermal growth factor and nerve growth factor (NGF) lead to significantly different temporal patterns of extracellular-signal-regulated kinase activation, and differential regulation of Ras and Rap1 have been implicated in mediating this temporal specificity. Now Sasagawa et al. derive a computational model that incorporates the known signalling interactions and identifies key points of regulation that control these processes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
TCR activation kinetics and feedback regulation in primary human T cells
Cell Communication and Signaling Open Access 14 January 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Vaudry, D., Stork, P. J., Lazarovici, P. & Eiden, L. E. Science 296, 1648–1649 (2002).
Chao, M. V. Cell 68, 995–997 (1992).
Marshall, C. J. Cell 80, 179–185 (1995).
Traverse, S., Gomez, N., Paterson, H., Marshall, C. & Cohen, P. Biochem. J. 288 (Pt 2), 351–355 (1992).
Brightman, F. A. & Fell, D. A. FEBS Lett. 482, 169–174 (2000).
York, R. D. et al. Mol. Cell Biol. 20, 8069–8083 (2000).
Kao, S., Jaiswal, R. K., Kolch, W. & Landreth, G. E. J. Biol. Chem. 276, 18169–18177 (2001).
Sasagawa, S., Ozaki, Y., Fujita, K. & Kuroda, S. Nature Cell Biol. 7, 365–373 (2005).
Schoeberl, B., Eichler-Jonsson, C., Gilles, E. D. & Muller, G. Nature Biotechnol. 20, 370–375 (2002).
Corbalan-Garcia, S., Yang, S. -S., Degenhardt, K. R. & Bar-Sagi, D. Mol. Cell Biol. 16, 5674–5682 (1996).
Meakin, S. O., MacDonald, J. I., Gryz, E. A., Kubu, C. J. & Verdi, J. M. J. Biol. Chem. 274, 9861–9870 (1999).
Ichiba, T. et al. J. Biol. Chem. 274, 14376–14381 (1999).
Jordan, J. D. et al. J. Biol. Chem. (2005).
Wu, C., Lai, C. F. & Mobley, W. C. J. Neurosci. 21, 5406–5416 (2001).
Ohba, Y., Kurokawa, K. & Matsuda, M. EMBO J. 22, 859–869 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stork, P. Directing NGF's actions: it's a Rap. Nat Cell Biol 7, 338–339 (2005). https://doi.org/10.1038/ncb0405-338
Issue Date:
DOI: https://doi.org/10.1038/ncb0405-338
This article is cited by
-
TCR activation kinetics and feedback regulation in primary human T cells
Cell Communication and Signaling (2013)