How cells establish and maintain polarity during directed cell migration remains poorly understood. Nishiya et al. now describe an integrin signalling complex that includes paxillin and GIT1, which limits activation of Rac to the leading edge of a migrating cell.
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References
Nishiya, N., Kiosses, W. B., Han, J. & Ginsberg, M. H. Nature Cell Biol. 7, 343–352 (2005).
Manahan, C.L., Iglesias, P.A., Long, Y. & Devreotes, P.N. Annu. Rev. Cell Dev. Biol. 20, 223–253 (2004).
Kimmel, A.R. & Firtel, R.A. Curr. Opin. Genet. Dev. 14, 540–549 (2004).
Ridley, A.J. et al. Science 302, 1704–1709 (2003).
Srinivasan, S. et al. J. Cell Biol. 160, 375–385 (2003).
Etienne-Manneville, S. & Hall, A. Cell 106, 489–498 (2001).
Mouneimne, G. et al. J. Cell Biol. 166, 697–708 (2004).
Cox, E.A., Sastry, S.K. & Huttenlocher, A. Mol. Biol. Cell. 12, 265–277 (2001).
Manabe, R.R., Kovalenko, M., Webb, D.J. & Horwitz, A.R. J. Cell Sci. 115, 1497–1510 (2002).
Liu, S. et al. Nature 402, 676–681.
Han, J., Rose, D.M., Woodside, D.G., Goldfinger, L.E. & Ginsberg, M.H. J. Biol. Chem. 278, 34845–34853 (2003).
Goldfinger, L.E., Han, J., Kiosses, W.B., Howe, A.K. & Ginsberg, M.H. J. Cell Biol. 162, 731–741 (2003).
Ambroise, Y., Yaspan, B., Ginsberg, M.H. & Boger, D.L. Chem. Biol. 9, 1219–1226 (2002).
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Huttenlocher, A. Cell polarization mechanisms during directed cell migration. Nat Cell Biol 7, 336–337 (2005). https://doi.org/10.1038/ncb0405-336
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DOI: https://doi.org/10.1038/ncb0405-336
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