Table of contents
March 2001, Volume 3 No 3 ppE65-330
About the coverEditorial
Big genome — big science? - pE65
doi:10.1038/35060137
Full Text - Big genome — big science? | PDF (117 KB) - Big genome — big science?
News and Views
Spindles cotton on to junctions, APC and EB1 - ppE67 - E68
Mariann Bienz
doi:10.1038/35060140
Recent work in Drosophila has shown that the adherens junctions of epithelial cells provide a planar cue to orientate mitotic spindles during symmetrical division. This planar cue depends on the function of E-APC and dEB1, homologues of the adenomatous polyposis coli (APC) tumour suppressor and of the microtubule-binding yeast protein Bim1.
Full Text - Spindles cotton on to junctions, APC and EB1 | PDF (116 KB) - Spindles cotton on to junctions, APC and EB1
Ran hits the ground running - ppE69 - E70
Claire E. Walczak
doi:10.1038/35060144
The identification of proteins that are important for microtubule nucleation, regulation of microtubule dynamics and spindle assembly has been an exciting area of research. A series of recent papers have now provided key insights into these processes by identifying downstream targets of Ran that result in aster formation and spindle assembly.
Full Text - Ran hits the ground running | PDF (89 KB) - Ran hits the ground running
Akt takes centre stage in cell-cycle deregulation - ppE71 - E73
Wafik S. El-Deiry
doi:10.1038/35060148
The universal cell-cycle inhibitor p21Cip1/WAF1 is phosphorylated and localized in the cytoplasm in Her2/neu-overexpressing breast cancers as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer.
Full Text - Akt takes centre stage in cell-cycle deregulation | PDF (161 KB) - Akt takes centre stage in cell-cycle deregulation
New tricks for an old dog? - ppE74 - E75
Markus Zettl & Michael Way
doi:10.1038/35060152
The Arp2/3 complex affects the rate of actin polymerization and promotes cellular actin assembly. Recent work has shown that cortactin is capable of stimulating the actin-nucleating activity of the Arp2/3 complex. In addition, more insight has been gained into how new actin-filament branches are formed and how actin patches in yeast are assembled.
Full Text - New tricks for an old dog? | PDF (93 KB) - New tricks for an old dog?
Book Reviews
Hershey and his heaven - pE77
Jonathan Hodgkin reviews We Can Sleep Later: Alfred D. Hershey and the Origins of Molecular Biology by
doi:10.1038/35060155
Full Text - Hershey and his heaven | PDF (95 KB) - Hershey and his heaven
Science for all - pE78
Andrew Aplin reviews The Establishment of Science in America by Sally Gregory Kohlstedt, Michael M. Sokal & Bruce V. Lewenstein
doi:10.1038/35060158
The true rise of the rising sun - pE79
Fuyuki Ishikawa reviews Science, Technology and Society in Contemporary Japan by M. Low, S. Nakayama & H. Yoshioka
doi:10.1038/35060161
Full Text - The true rise of the rising sun | PDF (88 KB) - The true rise of the rising sun
Review
The cell biology of neuronal navigation - ppE81 - E88
Hong-jun Song & Mu-ming Poo
doi:10.1038/35060164
Abstract - | Full Text - The cell biology of neuronal navigation | PDF (288 KB) - The cell biology of neuronal navigation
Articles
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities - pp221 - 227
Andrew Wilde, Sofia B. Lizarraga, Lijun Zhang, Christiane Wiese, Neal R. Gliksman, Claire E. Walczak & Yixian Zheng
doi:10.1038/35060000
Abstract - | Full Text - Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities | PDF (804 KB) - Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities
Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly - pp228 - 234
Rafael E. Carazo-Salas, Oliver J. Gruss, Iain W. Mattaj & Eric Karsenti
doi:10.1038/35060009
Abstract - | Full Text - Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly | PDF (1,102 KB) - Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly | Supplementary information
Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe - pp235 - 244
Robert J. Pelham, Jr & Fred Chang
doi:10.1038/35060020
Abstract - | Full Text - Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe | PDF (1,608 KB) - Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe | Supplementary information
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells - pp245 - 252
Binhua P. Zhou, Yong Liao, Weiya Xia, Bill Spohn, Mong-Hong Lee & Mien-Chie Hung
doi:10.1038/35060032
Abstract - | Full Text - Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells | PDF (459 KB) - Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
Sequential-replenishment mechanism of exocytosis in pancreatic acini - pp253 - 258
Tomomi Nemoto, Ryoichi Kimura, Koichi Ito, Akira Tachikawa, Yasushi Miyashita, Masamitsu Iino & Haruo Kasai
doi:10.1038/35060042
Abstract - | Full Text - Sequential-replenishment mechanism of exocytosis in pancreatic acini | PDF (655 KB) - Sequential-replenishment mechanism of exocytosis in pancreatic acini | Supplementary information
Activation of Arp2/3 complex-mediated actin polymerization by cortactin - pp259 - 266
Takehito Uruno, Jiali Liu, Peijun Zhang, Ying-xin Fan, Coumaran Egile, Rong Li, Susette C. Mueller & Xi Zhan
doi:10.1038/35060051
Abstract - | Full Text - Activation of Arp2/3 complex-mediated actin polymerization by cortactin | PDF (797 KB) - Activation of Arp2/3 complex-mediated actin polymerization by cortactin
A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation - pp267 - 275
Sushma Selvarajan, Leif R. Lund, Toshihiko Takeuchi, Charles S. Craik & Zena Werb
doi:10.1038/35060059
Abstract - | Full Text - A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation | PDF (1,965 KB) - A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation
Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth - pp276 - 282
Jaewhan Song, Masahiro Takeda & Richard I. Morimoto
doi:10.1038/35060068
Abstract - | Full Text - Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth | PDF (855 KB) - Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth
c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells - pp283 - 288
Riccardo Gavioli, Teresa Frisan, Simona Vertuani, Georg W. Bornkamm & Maria G. Masucci
doi:10.1038/35060076
Abstract - | Full Text - c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells | PDF (371 KB) - c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells
DNA replication control through interaction of E2F–RB and the origin recognition complex - pp289 - 295
Giovanni Bosco, Wei Du & Terry L. Orr-Weaver
doi:10.1038/35060086
Abstract - | Full Text - DNA replication control through interaction of E2F–RB and the origin recognition complex | PDF (910 KB) - DNA replication control through interaction of E2F–RB and the origin recognition complex | Supplementary information
Brief Communications
Distinct roles for G
and G
in regulating spindle position and orientation in Caenorhabditis elegans embryos - pp297 - 300
Monica Gotta & Julie Ahringer
doi:10.1038/35060092
Abstract - | Full Text - Distinct roles for G
and G
in regulating spindle position and orientation in Caenorhabditis elegans embryos | PDF (842 KB) - Distinct roles for G and G in regulating spindle position and orientation in Caenorhabditis elegans embryos | Supplementary information
Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade - pp301 - 305
Stephan Pleschka, Thorsten Wolff, Christina Ehrhardt, Gerd Hobom, Oliver Planz, Ulf R. Rapp & Stephan Ludwig
doi:10.1038/35060098
Abstract - | Full Text - Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade | PDF (959 KB) - Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade | Supplementary information
The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments - pp306 - 310
Kurt J. Amann & Thomas D. Pollard
doi:10.1038/35060104
Abstract - | Full Text - The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments | PDF (802 KB) - The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments
A myosin II mutation uncouples ATPase activity from motility and shortens step size - pp311 - 315
Coleen T. Murphy, Ronald S. Rock & James A. Spudich
doi:10.1038/35060110
Abstract - | Full Text - A myosin II mutation uncouples ATPase activity from motility and shortens step size | PDF (359 KB) - A myosin II mutation uncouples ATPase activity from motility and shortens step size
Rac recruits high-affinity integrin v3 to lamellipodia in endothelial cell migration - pp316 - 320
William B. Kiosses, Sanford J. Shattil, Nisar Pampori & Martin Alexander Schwartz
doi:10.1038/35060120
Abstract - | Full Text - Rac recruits high-affinity integrin v3 to lamellipodia in endothelial cell migration | PDF (1,477 KB) - Rac recruits high-affinity integrin v3 to lamellipodia in endothelial cell migration
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 - pp321 - 324
Dvora Ganoth, Gil Bornstein, Tun K. Ko, Brett Larsen, Mike Tyers, Michele Pagano & Avram Hershko
doi:10.1038/35060126
Abstract - | Full Text - The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 | PDF (471 KB) - The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 | Supplementary information
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation - pp325 - 330
Hasem Habelhah, Kavita Shah, Lan Huang, Antje Ostareck-Lederer, A. L. Burlingame, Kevan M. Shokat, Matthias W. Hentze & Ze'ev Ronai
doi:10.1038/35060131
Abstract - | Full Text - ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation | PDF (598 KB) - ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation
