Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 3 Issue 3, March 2001

Confocal microscopy picture showing the influenza A virus nucleoprotein (green), nuclear export protein (blue)and matrixprotein (red, showing as purple when superimposed with blue) trapped in the nucleus of an infected cell treated with the MEK inhibitor U0126. [Cover design: Majo Xeridat] [article, p301]

Volume 3 Issue 3

Subscribe

Article

Top of page ⤴

Brief Communication

Top of page ⤴

Editorial

Top of page ⤴

News & Views

  • Recent work in Drosophila has shown that the adherens junctions of epithelial cells provide a planar cue to orientate mitotic spindles during symmetrical division. This planar cue depends on the function of E-APC and dEB1, homologues of the adenomatous polyposis coli (APC) tumour suppressor and of the microtubule-binding yeast protein Bim1.

    • Mariann Bienz
    News & Views

  • The identification of proteins that are important for microtubule nucleation, regulation of microtubule dynamics and spindle assembly has been an exciting area of research. A series of recent papers have now provided key insights into these processes by identifying downstream targets of Ran that result in aster formation and spindle assembly.

    • Claire E. Walczak
    News & Views

  • The universal cell-cycle inhibitor p21Cip1/WAF1 is phosphorylated and localized in the cytoplasm in Her2/neu-overexpressing breast cancers as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer.

    • Wafik S. El-Deiry
    News & Views

  • The Arp2/3 complex affects the rate of actin polymerization and promotes cellular actin assembly. Recent work has shown that cortactin is capable of stimulating the actin-nucleating activity of the Arp2/3 complex. In addition, more insight has been gained into how new actin-filament branches are formed and how actin patches in yeast are assembled.

    • Markus Zettl
    • Michael Way
    News & Views
Top of page ⤴

Book Review

Top of page ⤴

Review Article

Top of page ⤴

Search

Advanced search

Quick links