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Editorial

Big genome — big science? pE65

doi:10.1038/35060137


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News and Views

Spindles cotton on to junctions, APC and EB1 ppE67 - E68

Mariann Bienz

doi:10.1038/35060140

Recent work in Drosophila has shown that the adherens junctions of epithelial cells provide a planar cue to orientate mitotic spindles during symmetrical division. This planar cue depends on the function of E-APC and dEB1, homologues of the adenomatous polyposis coli (APC) tumour suppressor and of the microtubule-binding yeast protein Bim1.


Ran hits the ground running ppE69 - E70

Claire E. Walczak

doi:10.1038/35060144

The identification of proteins that are important for microtubule nucleation, regulation of microtubule dynamics and spindle assembly has been an exciting area of research. A series of recent papers have now provided key insights into these processes by identifying downstream targets of Ran that result in aster formation and spindle assembly.


Akt takes centre stage in cell-cycle deregulation ppE71 - E73

Wafik S. El-Deiry

doi:10.1038/35060148

The universal cell-cycle inhibitor p21Cip1/WAF1 is phosphorylated and localized in the cytoplasm in Her2/neu-overexpressing breast cancers as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer.


New tricks for an old dog? ppE74 - E75

Markus Zettl & Michael Way

doi:10.1038/35060152

The Arp2/3 complex affects the rate of actin polymerization and promotes cellular actin assembly. Recent work has shown that cortactin is capable of stimulating the actin-nucleating activity of the Arp2/3 complex. In addition, more insight has been gained into how new actin-filament branches are formed and how actin patches in yeast are assembled.


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Book Reviews

Hershey and his heaven pE77

Jonathan Hodgkin reviews We Can Sleep Later: Alfred D. Hershey and the Origins of Molecular Biology by

doi:10.1038/35060155


Science for all pE78

Andrew Aplin reviews The Establishment of Science in America by Sally Gregory Kohlstedt, Michael M. Sokal & Bruce V. Lewenstein

doi:10.1038/35060158


The true rise of the rising sun pE79

Fuyuki Ishikawa reviews Science, Technology and Society in Contemporary Japan by M. Low, S. Nakayama & H. Yoshioka

doi:10.1038/35060161


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Review

The cell biology of neuronal navigation ppE81 - E88

Hong-jun Song & Mu-ming Poo

doi:10.1038/35060164


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Articles

Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities pp221 - 227

Andrew Wilde, Sofia B. Lizarraga, Lijun Zhang, Christiane Wiese, Neal R. Gliksman, Claire E. Walczak & Yixian Zheng

doi:10.1038/35060000


Ran–GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly pp228 - 234

Rafael E. Carazo-Salas, Oliver J. Gruss, Iain W. Mattaj & Eric Karsenti

doi:10.1038/35060009


Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe pp235 - 244

Robert J. Pelham, Jr & Fred Chang

doi:10.1038/35060020


Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells pp245 - 252

Binhua P. Zhou, Yong Liao, Weiya Xia, Bill Spohn, Mong-Hong Lee & Mien-Chie Hung

doi:10.1038/35060032


Sequential-replenishment mechanism of exocytosis in pancreatic acini pp253 - 258

Tomomi Nemoto, Ryoichi Kimura, Koichi Ito, Akira Tachikawa, Yasushi Miyashita, Masamitsu Iino & Haruo Kasai

doi:10.1038/35060042


Activation of Arp2/3 complex-mediated actin polymerization by cortactin pp259 - 266

Takehito Uruno, Jiali Liu, Peijun Zhang, Ying-xin Fan, Coumaran Egile, Rong Li, Susette C. Mueller & Xi Zhan

doi:10.1038/35060051


A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation pp267 - 275

Sushma Selvarajan, Leif R. Lund, Toshihiko Takeuchi, Charles S. Craik & Zena Werb

doi:10.1038/35060059


Bag1–Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth pp276 - 282

Jaewhan Song, Masahiro Takeda & Richard I. Morimoto

doi:10.1038/35060068


c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells pp283 - 288

Riccardo Gavioli, Teresa Frisan, Simona Vertuani, Georg W. Bornkamm & Maria G. Masucci

doi:10.1038/35060076


DNA replication control through interaction of E2F–RB and the origin recognition complex pp289 - 295

Giovanni Bosco, Wei Du & Terry L. Orr-Weaver

doi:10.1038/35060086


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Brief Communications


Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade pp301 - 305

Stephan Pleschka, Thorsten Wolff, Christina Ehrhardt, Gerd Hobom, Oliver Planz, Ulf R. Rapp & Stephan Ludwig

doi:10.1038/35060098


The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments pp306 - 310

Kurt J. Amann & Thomas D. Pollard

doi:10.1038/35060104


A myosin II mutation uncouples ATPase activity from motility and shortens step size pp311 - 315

Coleen T. Murphy, Ronald S. Rock & James A. Spudich

doi:10.1038/35060110


Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration pp316 - 320

William B. Kiosses, Sanford J. Shattil, Nisar Pampori & Martin Alexander Schwartz

doi:10.1038/35060120


The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27 pp321 - 324

Dvora Ganoth, Gil Bornstein, Tun K. Ko, Brett Larsen, Mike Tyers, Michele Pagano & Avram Hershko

doi:10.1038/35060126


ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation pp325 - 330

Hasem Habelhah, Kavita Shah, Lan Huang, Antje Ostareck-Lederer, A. L. Burlingame, Kevan M. Shokat, Matthias W. Hentze & Ze'ev Ronai

doi:10.1038/35060131


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