The universal cell-cycle inhibitor p21Cip1/WAF1 is phosphorylated and localized in the cytoplasm in Her2/neu-overexpressing breast cancers as a result of its physical association with the oncogenic Akt protein. Subcellular mislocalization of checkpoint controllers is now surfacing as a mechanism of deregulating cell proliferation in cancer.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
The macrophage: a therapeutic target in HIV-1 infection
Molecular and Cellular Therapies Open Access 02 April 2014
-
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
Retrovirology Open Access 31 January 2008
-
Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
BMC Cancer Open Access 26 April 2006
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Olayioye, M. A., Neve, R. M., Lane, H. A. & Hynes, N. E. EMBO J. 19, 3159–3167 (2000).
Dickman, S. Science 280, 1196–1197 ( 1998).
Harari, D. & Yarden, Y. Oncogene 19, 6102–6114 (2000).
Zhou, B. P. et al. Nature Cell Biol. 3, 245– 252 (2001).
Kennedy, S. G. et al. Genes Dev. 11, 701– 713 (1997).
Kauffman-Zeh, A. et al. Nature 385, 544–548 (1997).
Sasaki, T. et al. Nature 406, 897–902 (2000).
Verdu, J., Buratovich, M. A., Wilder, E. L. & Birnbaum, M. J. Nature Cell Biol. 1, 500–506 (1999).
Datta, S. R., Brunet, A. & Greenberg, M. E. Genes Dev. 13, 2905– 2927 (1999).
Franke, T. F. et al. Cell 81, 727–736 (1995).
Cristofano, A. D. & Pandolfi, P. P. Cell 100, 387–390 (2000).
Morgan, D. O. Nature 374, 131–134 ( 1995).
Sherr, C. J. & Roberts, J. M. Genes Dev. 13, 1501–1512 (1999).
Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W. & Vogelstein, B. Nature 401, 616–620 (1999).
Deng, C. X., Zhang, P. M., Harper, J. W., Elledge, S. J. & Leder, P. Cell 82, 675 –684 (1995).
Mitchell, K. & El-Deiry, W. S. Cell Growth Diff. 10, 223–230 (1999).
Missero, C., DiCunto, F., Kiyokawa, H., Koff, A. & Dotto, G. P. Genes Dev. 10, 3065–3075 (1996).
Jones, J. M., Cui, X. S., Medina, D. & Donehower, L. A. Cell Growth Diff. 10, 213–222 ( 1999).
Cheng, T. et al. Science 287, 1804–1808 (2000).
Yu, D. et al. Molecular Cell 2, 581–591 (1998).
Wen, Y. et al. Cancer Res. 60, 6841–6845 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
El-Deiry, W. Akt takes centre stage in cell-cycle deregulation. Nat Cell Biol 3, E71–E73 (2001). https://doi.org/10.1038/35060148
Issue Date:
DOI: https://doi.org/10.1038/35060148
This article is cited by
-
The macrophage: a therapeutic target in HIV-1 infection
Molecular and Cellular Therapies (2014)
-
Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy
Retrovirology (2008)
-
The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer
Oncogene (2007)
-
Genistein inhibits radiation-induced activation of NF-κB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
BMC Cancer (2006)
-
EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization
Breast Cancer Research and Treatment (2006)
