Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Ran hits the ground running

The identification of proteins that are important for microtubule nucleation, regulation of microtubule dynamics and spindle assembly has been an exciting area of research. A series of recent papers have now provided key insights into these processes by identifying downstream targets of Ran that result in aster formation and spindle assembly.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2: Importin-β sequesters factors that are important for microtubule polymerization.

References

  1. Kalab, P., Pu, R. T. & Dasso, M. Curr. Biol. 9, 481–484 (1999).

    Article  CAS  Google Scholar 

  2. Ohba, T., Nakamura, M., Nishitani, H. & Nishimoto, T. Science 284, 1356–1358 (1999).

    Article  CAS  Google Scholar 

  3. Zhang, C., Hughes, M. & Clarke, P. R. J. Cell Sci. 112, 2453–2461 (1999).

    CAS  PubMed  Google Scholar 

  4. Wilde, A. & Zheng, Y. Science 284, 1359–1362 (1999).

    Article  CAS  Google Scholar 

  5. Carazo-Salas, R. E. et al. Nature 400, 178–181 (1999).

    Article  CAS  Google Scholar 

  6. Sazer, S. & Dasso, M. J. Cell Sci. 113, 1111–1118 (2000).

    CAS  PubMed  Google Scholar 

  7. Kahana, J. A. & Cleveland, D. W. J. Cell Biol. 146, 1205–1210 (1999).

    Article  CAS  Google Scholar 

  8. Nishimoto, T. Biochem. Biophys. Res. Commun. 262, 571–574 (1999).

    Article  CAS  Google Scholar 

  9. Wilde, A. et al. Nature Cell Biol. 3, 221–227 (2001).

    Article  CAS  Google Scholar 

  10. Carazo-Salas, R. E., Gruss, O., Mattaj, I. W. & Karsenti, E. Nature Cell Biol. 3, 228–234 (2001).

    Article  CAS  Google Scholar 

  11. Gruss, O. J. et al. Cell 104, 83–93 (2001).

    Article  CAS  Google Scholar 

  12. Nachury, M. V. et al. Cell 104, 95–106 (2001).

    Article  CAS  Google Scholar 

  13. Wiese, C. et al. Science 291, 653–656 (2001).

    Article  CAS  Google Scholar 

  14. Walczak, C. E. & Mitchison, T. J. Cell 85, 943–946 (1996).

    Article  CAS  Google Scholar 

  15. Azuma, Y. & Dasso, M. Curr. Opin. Cell Biol. 12, 302–307 (2000).

    Article  CAS  Google Scholar 

  16. Wittmann, T., Wilm, M., Karsenti, E. & Vernos, I. J. Cell Biol. 149, 1405–1418 (2000).

    Article  CAS  Google Scholar 

  17. Merdes, A., Ramyar, K., Vechio, J. D. & Cleveland, D. W. Cell 87, 447–458 (1996).

    Article  CAS  Google Scholar 

  18. Gaglio, T., Saredi, A. & Compton, D. A. J. Cell Biol. 131, 693–708 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walczak, C. Ran hits the ground running. Nat Cell Biol 3, E69–E70 (2001). https://doi.org/10.1038/35060144

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35060144

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing