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Volume 10 Issue 8, August 2008

Rag GTPases promote nutrient-dependent activation of TOR-regulated cell growth. In the presence of nutrients, RagC mutant cells (GFP-negative) are smaller than surrounding wild-type cells (GFP-positive).article p935

Volume 10 Issue 8

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Editorial

  • At a time when change is necessary, French researchers are on the barricades resisting efforts to reform CNRS, the country's well respected basic research agency.

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News & Views

  • The mammalian target of rapamycin (mTOR) controls cell growth and size. Amino acids are known to activate TOR, and Rag (Ras-related GTP-binding protein) GTPases have now been found to act as their effectors.

    • Alfred J. Meijer
    • Patrice Codogno
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  • Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and β-catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.

    • Julie Gavard
    • J. Silvio Gutkind
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  • In endocrine cells, secretion can be rapidly upregulated in response to stimuli without the need for additional synthesis of transport components. A new and unexpected function of KDEL-R as a signalling receptor that senses cargo protein load in the early secretory pathway has been identified.

    • Lennart Asp
    • Tommy Nilsson
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  • Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Unexpected findings now identify multiple secreted inflammatory cytokines, their cognate receptors and positive-feedback loops with corresponding transcription factors, as key mediators of both oncogene-induced and replicative senescence.

    • Jiri Bartek
    • Zdenek Hodny
    • Jiri Lukas
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