Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and β-catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.
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References
Yap, A.S., Brieher, W.M. & Gumbiner, B.M. Annu. Rev. Cell. Dev. Biol. 13, 119–146 (1997).
Tsukita, S., Furuse, M. & Itoh, M. Nature Rev. Mol. Cell Biol. 2, 285–293 (2001).
Dejana, E. Nature Rev. Mol. Cell Biol. 5, 261–270 (2004).
Taddei, A. et al. Nature Cell Biol. 10, 923–934 (2008).
Nelson, W.J. & Nusse, R. Science 303, 1483–1487 (2004).
Rhee, J., Buchan, T., Zukerberg, L., Lilien, J. & Balsamo, J. Nature Cell Biol. 9, 883–892 (2007).
Hoogeboom, D. et al. J. Biol. Chem. 283, 9224–9230 (2008).
Nitta, T. et al. J. Cell Biol. 161, 653–660 (2003).
Carmeliet, P. et al. Cell 98, 147–57 (1999).
Lampugnani, M.G., Orsenigo, F., Gagliani, M.C., Tacchetti, C. & Dejana, E. J. Cell Biol. 174, 593–604 (2006).
Gavard, J. & Gutkind, J.S. Nature Cell Biol. 8, 1223–1234 (2006).
Weis, S. et al. J. Clin. Invest. 113, 885–894 (2004).
Orlova, V.V., Economopoulou, M., Lupu, F., Santoso, S. & Chavakis, T. J. Exp. Med. 203, 2703–2714 (2006).
van Wetering, S. et al. J. Cell Sci. 115, 1837–1846 (2002).
Essers, M.A.G. et al. Science 308, 1181–1184 (2005).
Paul, R. et al. Nature Med. 7, 222–227 (2001).
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Gavard, J., Gutkind, J. VE-cadherin and claudin-5: it takes two to tango. Nat Cell Biol 10, 883–885 (2008). https://doi.org/10.1038/ncb0808-883
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DOI: https://doi.org/10.1038/ncb0808-883
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