Intracellular force reconstruction of migrating epithelial cells by quantitative fluorescent speckle microscopy. Predicted force fields were derived from F-actin speckle data.

[article p1393]

A confocal section through a mouse embryonic hair follicle that has lost asymmetry due to a mutation in the Vangl2 gene. E-Cadherin (red) marks cell borders, Celsr1 (green) is abnormally diffuse.

[article p 1257]

O-GlcNac modifications (green) on the translation machinery promote stress granule assembly (blue) and P-bodies (red) in arsenite-treated cells.letter p1224

Images showing the extent of 'wound healing' after knockdown of 1081 genes in breast epithelial cells. This analysis identified 66 highly validated genes whose knockdown caused either acceleration or impairment of cell migration and involves diverse alterations in cellular processes.article p1027

Rag GTPases promote nutrient-dependent activation of TOR-regulated cell growth. In the presence of nutrients, RagC mutant cells (GFP-negative) are smaller than surrounding wild-type cells (GFP-positive).article p935

Section through the primitive streak of a gastrulation-stage chick embryo stained for nuclei (cyan), RhoA (red) and laminin (green). The loss of basal RhoA coincides with that of the basement membrane. [article p765]

The presence of extra chromosomes and/or centrosomes prolongs the duration of mitosis. The image depicts a tetraploid human spindle during prometaphase. Triple-staining for centrosomes (green), microtubules (red) and DNA (white).letter p748

Heterotypic fusion of bone marrow-derived cells (BMDCs) with Purkinje neurons is enhanced by chronic inflammation. Confocal image of a cerebellar sagittal section from a mouse with dermatitis previously transplanted with GFP-expressing bone marrow. The presence of GFP in several heterokaryons (green/yellow) indicates fusion of BMDCs with Purkinje neurons (red, calbindin).[letter p575]

Epifluorescence image of Zebrafish germ-layer progenitor-cell sorting in a hanging drop assay in vitro. Cells will self-sort according to their cortical tensions and mesoderm cell clusters (green) will always envelop ectoderm cell clusters (red).

Hypertrophy of the pericentriolar material (PCM) results in the formation of multiple daughter centrioles on the same mother. A montage is shown of triple-stained centrosomes from CHO cells arrested in S phase. SAS-6 (red) localizes to the proximal end of daughter centrioles; centrin localizes to the distal end of all centrioles (green) and the PCM is marked by g-tubulin (blue).

In the Drosophila wing imaginal disc, retromer is required for Wnts to promote Wntless accumulation (in white, horizontal Wntless stripe induced by endogenous Wingless and vertical Wntless induced by ectopic Wnt).

In addition to promoting Hedgehog signalling, cilia (shown here in blue in the mouse node) also restrain Wnt signalling.