The mammalian target of rapamycin (mTOR) controls cell growth and size. Amino acids are known to activate TOR, and Rag (Ras-related GTP-binding protein) GTPases have now been found to act as their effectors.
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References
Blommaart, E.F., Luiken, J.J., Blommaart, P.J., van Woerkom, G.M. & Meijer, A.J. J. Biol. Chem. 270, 2320–2326 (1995).
Hara, K. et al. J. Biol. Chem. 273, 14484–14494 (1998).
Kim, E., Gorakshah-Hicks, P., Li, L., Neufeld, T.P. & Guan, K.L. Nature Cell Biol. 10, 935–945 (2008).
Sancak, Y. et al. Science 320, 1496–1501 (2008).
Inoki, K., Corradetti, M.N. & Guan, K.L. Nature Genet. 37, 19–24 (2005).
Nobukuni, T. et al. Proc. Natl Acad. Sci. USA 102, 14238–14243 (2005).
Klionsky, D.J. Nature Rev. Mol. Cell Biol. 8, 931–937 (2007).
Levine, B. & Kroemer, G. Cell. 132, 27–42 (2008).
Scott, R.C., Juhasz, G. & Neufeld, T.P. Curr. Biol. 17, 1–11 (2007).
Gulati, P. et al. Cell Metab. 7, 456–465 (2008).
Petiot, A., Ogier-Denis, E., Blommaart, E.F., Meijer, A.J. & Codogno, P. J. Biol Chem. 275, 992–998 (2000).
Juhasz, G. et al. J. Cell Biol. 181, 655–666 (2008).
Long, X., Ortiz-Vega, S., Lin, Y. & Avruch, J. J. Biol Chem. 280, 23433–23436 (2005).
Dubbelhuis, P.F. & Meijer, A.J. FEBS Lett. 521, 39–42 (2002).
Gwinn, D.M. et al. Mol. Cell. 30, 214–226 (2008).
McCormack, J.G. & Denton, R.M. Dev. Neurosci. 15, 165–173 (1993).
Um, S.H., D'Alessio, D. & Thomas, G. Cell Metab 3, 393–402 (2006).
Cuervo, A.M. et al. Autophagy 1, 131–140 (2005).
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Meijer, A., Codogno, P. Nutrient sensing: TOR's Ragtime. Nat Cell Biol 10, 881–883 (2008). https://doi.org/10.1038/ncb0808-881
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DOI: https://doi.org/10.1038/ncb0808-881
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