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Volume 10 Issue 6, June 2008

The presence of extra chromosomes and/or centrosomes prolongs the duration of mitosis. The image depicts a tetraploid human spindle during prometaphase. Triple-staining for centrosomes (green), microtubules (red) and DNA (white).letter p748

Volume 10 Issue 6

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  • Transforming growth factor-β (TGF-β) stimulates phosphorylation of TGF-β type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.

    • Kohei Miyazono
    • Yuto Kamiya
    • Keiji Miyazawa
    News & Views

  • The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

    • Beth Levine
    • John Abrams
    News & Views

  • Store-operated Ca2+ channels (SOCs) are activated in response to Ca2+ release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca2+ content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.

    • Dong Min Shin
    • Shmuel Muallem
    News & Views
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