Missing the boat: a loophole in start-up funding? - p629

doi:10.1038/ncb0608-629

Funding agencies have set up dedicated schemes to help the plight of young principal investigators. But is the playing field level for all qualified scientists?

Full Text - Missing the boat: a loophole in start-up funding? | PDF (252 KB) - Missing the boat: a loophole in start-up funding?

Small RNAs tell big stories in Whistler - pp630 - 633

Amy C. Seila & Phillip A. Sharp

doi:10.1038/ncb0608-630

Abstract - | Full Text - Small RNAs tell big stories in Whistler | PDF (968 KB) - Small RNAs tell big stories in Whistler

SUMO amplifies TGF- signalling - pp635 - 637

Kohei Miyazono, Yuto Kamiya & Keiji Miyazawa

doi:10.1038/ncb0608-635

Transforming growth factor- (TGF-) stimulates phosphorylation of TGF- type I receptor. This receptor is now shown to be sumoylated, leading to enhanced activation and modulation of the downstream Smad signalling pathway.

Full Text - SUMO amplifies TGF- signalling | PDF (342 KB) - SUMO amplifies TGF- signalling

See also: Article by Kang et al.

p53: The Janus of autophagy? - pp637 - 639

Beth Levine & John Abrams

doi:10.1038/ncb0608-637

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

Full Text - p53: The Janus of autophagy? | PDF (319 KB) - p53: The Janus of autophagy?

See also: Article by Tasdemir et al.

Skeletal muscle dressed in SOCs - pp639 - 641

Dong Min Shin & Shmuel Muallem

doi:10.1038/ncb0608-639

Store-operated Ca²⁺ channels (SOCs) are activated in response to Ca²⁺ release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca²⁺ content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.

Full Text - Skeletal muscle dressed in SOCs | PDF (566 KB) - Skeletal muscle dressed in SOCs

See also: Article by Stiber et al.

Research highlights - p642

doi:10.1038/ncb0608-642

Full Text - Research highlights | PDF (214 KB) - Research highlights

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein - pp643 - 653

Xudong Zhao, Julian Ik-Tsen Heng, Daniele Guardavaccaro, Richeng Jiang, Michele Pagano, Francois Guillemot, Antonio Iavarone & Anna Lasorella

doi:10.1038/ncb1727

Abstract - | Full Text - The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein | PDF (22,905 KB) - The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein | Supplementary information

The type I TGF- receptor is covalently modified and regulated by sumoylation - pp654 - 664

Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst & Rik Derynck

doi:10.1038/ncb1728

Abstract - | Full Text - The type I TGF- receptor is covalently modified and regulated by sumoylation | PDF (2,279 KB) - The type I TGF- receptor is covalently modified and regulated by sumoylation | Supplementary information

See also: News and Views by Miyazono et al.

Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle - pp665 - 675

Karen Crasta, Hong Hwa Lim, Thomas H. Giddings, Jr, Mark Winey & Uttam Surana

doi:10.1038/ncb1729

Abstract - | Full Text - Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle | PDF (2,793 KB) - Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle | Supplementary information

Regulation of autophagy by cytoplasmic p53 - pp676 - 687

Ezgi Tasdemir, M. Chiara Maiuri, Lorenzo Galluzzi, Ilio Vitale, Mojgan Djavaheri-Mergny, Marcello D'Amelio, Alfredo Criollo, Eugenia Morselli, Changlian Zhu, Francis Harper, Ulf Nannmark, Chrysanthi Samara, Paolo Pinton, José Miguel Vicencio, Rosa Carnuccio, Ute M. Moll, Frank Madeo, Patrizia Paterlini-Brechot, Rosario Rizzuto, Gyorgy Szabadkai, Gérard Pierron, Klas Blomgren, Nektarios Tavernarakis, Patrice Codogno, Francesco Cecconi & Guido Kroemer

doi:10.1038/ncb1730

Abstract - | Full Text - Regulation of autophagy by cytoplasmic p53 | PDF (4,073 KB) - Regulation of autophagy by cytoplasmic p53 | Supplementary information

See also: News and Views by Levine & Abrams

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle - pp688 - 697

Jonathan Stiber, April Hawkins, Zhu-Shan Zhang, Sunny Wang, Jarrett Burch, Victoria Graham, Cary C. Ward, Malini Seth, Elizabeth Finch, Nadia Malouf, R. Sanders Williams, Jerry P. Eu & Paul Rosenberg

doi:10.1038/ncb1731

Abstract - | Full Text - STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle | PDF (2,817 KB) - STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle | Supplementary information

See also: News and Views by Shin & Muallem

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B - pp698 - 706

Xiaoling Tang, Sung-Wuk Jang, Masashi Okada, Chi-Bun Chan, Yue Feng, Yu Liu, Shi-Wen Luo, Yan Hong, Nicolas Rama, Wen-Cheng Xiong, Patrick Mehlen & Keqiang Ye

doi:10.1038/ncb1732

First Paragraph - | Full Text - Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B | PDF (2,113 KB) - Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B | Supplementary information

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export - pp707 - 715

Alwin Köhler, Maren Schneider, Ghislain G. Cabal, Ulf Nehrbass & Ed Hurt

doi:10.1038/ncb1733

First Paragraph - | Full Text - Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export | PDF (2,586 KB) - Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export | Supplementary information

1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells - pp716 - 722

Ilaria Taddei, Marie-Ange Deugnier, Marisa M. Faraldo, Valérie Petit, Daniel Bouvard, Daniel Medina, Reinhard Fässler, Jean Paul Thiery & Marina A. Glukhova

doi:10.1038/ncb1734

First Paragraph - | Full Text - 1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells | PDF (3,208 KB) - 1 Integrin deletion from the basal compartment of the mammary epithelium affects stem cells | Supplementary information

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation - pp723 - 730

Maria Emanuela Cuomo, Axel Knebel, Nick Morrice, Hugh Paterson, Philip Cohen & Sibylle Mittnacht

doi:10.1038/ncb1735

First Paragraph - | Full Text - p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation | PDF (2,818 KB) - p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation | Supplementary information

Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells - pp731 - 739

Jiancong Liang, Ma Wan, Yi Zhang, Peili Gu, Huawei Xin, Sung Yun Jung, Jun Qin, Jiemin Wong, Austin J. Cooney, Dan Liu & Zhou Songyang

doi:10.1038/ncb1736

First Paragraph - | Full Text - Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells | PDF (2,281 KB) - Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells | Supplementary information

An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway - pp740 - 747

Scott W. Rowlinson, Hideo Yoshizato, Johanna L. Barclay, Andrew J. Brooks, Stuart N. Behncken, Linda M. Kerr, Kirstin Millard, Kathryn Palethorpe, Katherine Nielsen, Jodie Clyde-Smith, John F. Hancock & Michael J. Waters

doi:10.1038/ncb1737

First Paragraph - | Full Text - An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway | PDF (2,114 KB) - An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway | Supplementary information

Extra centrosomes and/or chromosomes prolong mitosis in human cells - pp748 - 751

Zhenye Yang, Jadranka Lonarek, Alexey Khodjakov & Conly L. Rieder

doi:10.1038/ncb1738

Abstract - | Full Text - Extra centrosomes and/or chromosomes prolong mitosis in human cells | PDF (1,519 KB) - Extra centrosomes and/or chromosomes prolong mitosis in human cells | Supplementary information

Erratum - p752

doi:10.1038/ncb0608-752

Full Text - Erratum | PDF (261 KB) - Erratum