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Skeletal muscle dressed in SOCs

Nature Cell Biology volume 10, pages 639–641 (2008)Cite this article

Store-operated Ca2+ channels (SOCs) are activated in response to Ca2+ release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca2+ content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.

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Figure 1: The role of STIM1-regulated SOCs in skeletal muscle Ca2+ homeostasis.

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Authors and Affiliations

  1. Dong Min Shin is in the Department of Oral Biology, Yonsei University College of Dentistry, Seoul 120-752, Korea.,

    Dong Min Shin

  2. Shmuel Muallem is in the Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235-9040, USA. shmuel.muallem@utsouthwestern.edu,

    Shmuel Muallem

Authors
  1. Dong Min Shin
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  2. Shmuel Muallem
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Shin, D., Muallem, S. Skeletal muscle dressed in SOCs. Nat Cell Biol 10, 639–641 (2008). https://doi.org/10.1038/ncb0608-639

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