Table of contents
ARTICLE NAVIGATION - ISSUE
April 2008, Volume 10 No 4 pp371-496
About the coverEditorial
Good review - p371
doi:10.1038/ncb0408-371
Much has been said about alternatives and enhancements to 'single-blind' peer review; but what actually constitutes a good referee report?
News and Views
Neurogenesis directed by Sirt1 - pp373 - 374
Sergiy Libert, Dena Cohen & Leonard Guarente
doi:10.1038/ncb0408-373
Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.
Full Text - Neurogenesis directed by Sirt1 | PDF (256 KB) - Neurogenesis directed by Sirt1
Sophistications of cell sorting - pp375 - 377
Jeremy B.A. Green
doi:10.1038/ncb0408-375
The self-sorting of early embryonic cells is mediated not only by pure differential adhesion but also involves other processes. Direct force measurements reveal the role of cell-cortical tension, whereas epithelial-wrapping dominates the sorting of enclosed mesenchymal cells.
Full Text - Sophistications of cell sorting | PDF (3,202 KB) - Sophistications of cell sorting
BRCA1 and stem cells: tumour typecasting - pp377 - 379
Matthew J. Smalley, Jorge S. Reis-Filho & Alan Ashworth
doi:10.1038/ncb0408-377
Phenotypic variation between tumour types is likely to reflect the nature of the cell of origin and the genes involved in pathogenesis. Compared with most sporadic breast cancers, those arising in carriers of BRCA1 mutations usually have distinctive pathological characteristics. A new study suggests that a role for BRCA1 in the determination of stem-cell fate may explain this phenomenon.
Full Text - BRCA1 and stem cells: tumour typecasting | PDF (291 KB) - BRCA1 and stem cells: tumour typecasting
Dam1 complexes go it alone on disassembling microtubules - pp379 - 381
Melissa K. Gardner & David J. Odde
doi:10.1038/ncb0408-379
Kinetochores maintain a mechanical grip on disassembling microtubule plus ends, possibly through a 16-member Dam1 ring that acts as a sliding clamp. It turns out, however, that a ring is not required for maintaining grip: individual Dam1 complexes in vitro can diffuse on the microtubule lattice and track shortening microtubule tips.
Full Text - Dam1 complexes go it alone on disassembling microtubules | PDF (204 KB) - Dam1 complexes go it alone on disassembling microtubules
Securin' M-phase entry - pp381 - 383
Mark J. Solomon & Janet L. Burton
doi:10.1038/ncb0408-381
The anaphase-promoting complex (APC) mediates the ubiquitination and degradation of key M-phase regulators, including cyclins and the anaphase inhibitor securin. Intriguingly, securin can also inhibit the degradation of cyclin B. This competition between substrates permits the accumulation of enough cyclin to drive entry into M phase.
Full Text - Securin' M-phase entry | PDF (262 KB) - Securin' M-phase entry
STIM1 tracks growing microtubule ends - p384
Andrew Jermy
doi:10.1038/ncb0408-384
Full Text - STIM1 tracks growing microtubule ends | PDF (262 KB) - STIM1 tracks growing microtubule ends
Articles
Sirt1 contributes critically to the redox-dependent fate of neural progenitors - pp385 - 394
Timour Prozorovski, Ulf Schulze-Topphoff, Robert Glumm, Jan Baumgart, Friederike Schröter, Olaf Ninnemann, Elise Siegert, Ivo Bendix, Oliver Brüstle, Robert Nitsch, Frauke Zipp & Orhan Aktas
doi:10.1038/ncb1700
Abstract - Sirt1 contributes critically to the redox-dependent fate of neural progenitors | Full Text - Sirt1 contributes critically to the redox-dependent fate of neural progenitors | PDF (1,629 KB) - Sirt1 contributes critically to the redox-dependent fate of neural progenitors | Supplementary information
See also: News and Views by Libert et al.
Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast - pp395 - 406
Alberto Sanchez-Diaz, Vanessa Marchesi, Stephen Murray, Richard Jones, Gislene Pereira, Ricky Edmondson, Terry Allen & Karim Labib
doi:10.1038/ncb1701
Abstract - Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast | Full Text - Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast | PDF (3,661 KB) - Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast | Supplementary information
Letters
Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation - pp407 - 414
Daniel R. Gestaut, Beth Graczyk, Jeremy Cooper, Per O. Widlund, Alex Zelter, Linda Wordeman, Charles L. Asbury & Trisha N. Davis
doi:10.1038/ncb1702
First Paragraph - Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation | Full Text - Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation | PDF (1,187 KB) - Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation | Supplementary information
See also: News and Views by Gardner & Odde
EB1 regulates microtubule dynamics and tubulin sheet closure in vitro - pp415 - 421
Benjamin Vitre, Frédéric M. Coquelle, Claire Heichette, Cyrille Garnier, Denis Chrétien & Isabelle Arnal
doi:10.1038/ncb1703
First Paragraph - EB1 regulates microtubule dynamics and tubulin sheet closure : in vitro | Full Text - EB1 regulates microtubule dynamics and tubulin sheet closure in vitro | PDF (1,224 KB) - EB1 regulates microtubule dynamics and tubulin sheet closure in vitro | Supplementary information
The NHL-domain protein Wech is crucial for the integrin–cytoskeleton link - pp422 - 428
Birgit Löer, Reinhard Bauer, Roland Bornheim, Jessica Grell, Elisabeth Kremmer, Waldemar Kolanus & Michael Hoch
doi:10.1038/ncb1704
First Paragraph - The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link | Full Text - The NHL-domain protein Wech is crucial for the integrin–cytoskeleton link | PDF (2,236 KB) - The NHL-domain protein Wech is crucial for the integrin–cytoskeleton link | Supplementary information
Tensile forces govern germ-layer organization in zebrafish - pp429 - 436
M. Krieg, Y. Arboleda-Estudillo, P.-H. Puech, J. Käfer, F. Graner, D. J. Müller & C.-P. Heisenberg
doi:10.1038/ncb1705
First Paragraph - Tensile forces govern germ-layer organization in zebrafish | Full Text - Tensile forces govern germ-layer organization in zebrafish | PDF (2,356 KB) - Tensile forces govern germ-layer organization in zebrafish | Supplementary information
See also: News and Views by Green
elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8 - pp437 - 444
Yoshihiro Omori, Chengtian Zhao, Arunesh Saras, Saikat Mukhopadhyay, Woong Kim, Takahisa Furukawa, Piali Sengupta, Alexey Veraksa & Jarema Malicki
doi:10.1038/ncb1706
First Paragraph - elipsa: is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8 | Full Text - elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8 | PDF (2,473 KB) - elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8 | Supplementary information
Securin regulates entry into M-phase by modulating the stability of cyclin B - pp445 - 451
Petros Marangos & John Carroll
doi:10.1038/ncb1707
First Paragraph - Securin regulates entry into M-phase by modulating the stability of cyclin B | Full Text - Securin regulates entry into M-phase by modulating the stability of cyclin B | PDF (765 KB) - Securin regulates entry into M-phase by modulating the stability of cyclin B | Supplementary information
See also: News and Views by Solomon & Burton
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing - pp452 - 459
Paola Scaffidi & Tom Misteli
doi:10.1038/ncb1708
First Paragraph - Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing | Full Text - Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing | PDF (1,814 KB) - Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing | Supplementary information
Functional interaction between FOXO3a and ATM regulates DNA damage response - pp460 - 467
Wen-Bin Tsai, Young Min Chung, Yoko Takahashi, Zhaohui Xu & Mickey C.-T. Hu
doi:10.1038/ncb1709
First Paragraph - Functional interaction between FOXO3a and ATM regulates DNA damage response | Full Text - Functional interaction between FOXO3a and ATM regulates DNA damage response | PDF (3,191 KB) - Functional interaction between FOXO3a and ATM regulates DNA damage response | Supplementary information
Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling - pp468 - 475
Kyu-Sun Lee, O-Yu Kwon, Joon H. Lee, Kisang Kwon, Kyung-Jin Min, Sun-Ah Jung, Ae-Kyeong Kim, Kwan-Hee You, Marc Tatar & Kweon Yu
doi:10.1038/ncb1710
First Paragraph - Drosophila: short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling | Full Text - Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling | PDF (2,296 KB) - Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling | Supplementary information
A bistable Rb–E2F switch underlies the restriction point - pp476 - 482
Guang Yao, Tae Jun Lee, Seiichi Mori, Joseph R. Nevins & Lingchong You
doi:10.1038/ncb1711
First Paragraph - A bistable Rb-E2F switch underlies the restriction point | Full Text - A bistable Rb–E2F switch underlies the restriction point | PDF (2,342 KB) - A bistable Rb–E2F switch underlies the restriction point | Supplementary information
Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells - pp483 - 488
Neri Minsky, Efrat Shema, Yair Field, Meromit Schuster, Eran Segal & Moshe Oren
doi:10.1038/ncb1712
First Paragraph - Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells | Full Text - Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells | PDF (532 KB) - Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells | Supplementary information
Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability - pp489 - 496
Song Shi, Kimberly Larson, Dongdong Guo, Su Jun Lim, Pranabananda Dutta, Shian-Jang Yan & Willis X. Li
doi:10.1038/ncb1713
First Paragraph - Drosophila: STAT is required for directly maintaining HP1 localization and heterochromatin stability | Full Text - Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability | PDF (1,858 KB) - Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability | Supplementary information