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Securin' M-phase entry

Nature Cell Biology volume 10, pages 381–383 (2008)Cite this article

The anaphase-promoting complex (APC) mediates the ubiquitination and degradation of key M-phase regulators, including cyclins and the anaphase inhibitor securin. Intriguingly, securin can also inhibit the degradation of cyclin B. This competition between substrates permits the accumulation of enough cyclin to drive entry into M phase.

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Figure 1: Substrate- and inhibitor-binding to the APC.

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Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry, Mark J. Solomon and Janet L. Burton are at Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8024, USA. Mark.Solomon@yale.edu,

    Mark J. Solomon & Janet L. Burton

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  1. Mark J. Solomon
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  2. Janet L. Burton
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Solomon, M., Burton, J. Securin' M-phase entry. Nat Cell Biol 10, 381–383 (2008). https://doi.org/10.1038/ncb0408-381

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