A synthetic strategy has been developed that provides easy access to structurally diverse analogues of naturally occurring antibiotics, providing a fresh means of attack in the war against drug-resistant bacteria. See Article p.338
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References
Seiple, I. B. et al. Nature 533, 338–345 (2016).
Wright, P. M., Seiple, I. B. & Myers, A. G. Angew. Chem. Int. Edn 53, 8840–8869 (2014).
Keasling, J. D., Mendoza, A. & Baran, P. S. Nature 492, 188–189 (2012).
Parenty, A., Moreau, X., Niel, G. & Campagne, J.-M. Chem. Rev. 113, PR1–PR40 (2013).
Kuttruff, C. A., Eastgate, M. D. & Baran, P. S. Nat. Prod. Rep. 31, 419–432 (2014).
Seiple, I. B., Mercer, J. A. M., Sussman, R. J., Zhang, Z. & Myers, A. G. Angew. Chem. Int. Edn 53, 4642–4647 (2014).
Zhang, Z., Fukuzaki, T. & Myers, A. G. Angew. Chem. Int. Edn 55, 523–527 (2016).
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Yan, M., Baran, P. Fighting evolution with chemical synthesis. Nature 533, 326–327 (2016). https://doi.org/10.1038/533326a
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DOI: https://doi.org/10.1038/533326a
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