Genetics: Genius on the fly

Journal name:
Nature
Volume:
516,
Page:
169
Date published:
DOI:
doi:10.1038/516169a
Published online

Ewen Callaway reviews a biopic of Calvin Bridges, the wild-living, wild-haired genetics pioneer.

The Fly Room

Writer/Director: Alexis Gambis Imaginal Disc: 2014.

Calvin Bridges is best known for three things: his pioneering work on genetics in the early twentieth century, his womanizing and his gravity-defying mop of hair. The Fly Room, a biopic told through the eyes of his daughter Betsey, also shows the scientist as a sometimes dedicated, often distracted father who struggled to balance intellectual curiosity with family obligations.

The Fly Room came from a chance encounter between geneticist-turned-filmmaker Alexis Gambis and Betsey, now in her nineties. It is bookended by interviews with her, but focuses on a period in the 1920s, when ten-year-old Betsey visited her father's workplace: the famed Fly Room at Columbia University in New York City. The film was partly crowdfunded through Kickstarter. Researchers including neuroscientists Joseph LeDoux and Stuart Firestein have supporting roles.

Betsey Bridges Black Collection

Calvin Bridges experimented on fruit flies to make fundamental discoveries in genetics.

Bridges, portrayed by a wild-haired Haskell King, was a star disciple of evolutionary biologist Thomas Hunt Morgan (played by Firestein). Under Morgan's leadership, Bridges and a cadre of Young Turks characterized mutant fruit flies — most famously, white-eyed varieties — to map the locations of genes and to understand how they are transmitted. Bridges' work established that trait-determining genes are carried by chromosomes that parents pass to their offspring. He also worked out how chromosomes — X and Y — determine the sex of fruit flies.

“It was not unusual for six of us to carry on in this small room,” Morgan remembered in an obituary of Bridges, who died in 1938 from syphilis. To feed the flies, near-rotting bananas were a constant presence.

Imaginal Disc/LLC

Those bananas dangle from the ceiling in the film's fictionalized Fly Room, where Bridges and other prominent figures in genetics sort dead flies and trade rude witticisms. Betsey crashes this world after her mother, Gertrude, sends her to spend time with her father. None of the scientists knows what to make of the curious girl, who carries her box camera everywhere. Bridges is annoyed to have his sanctum disturbed. But he warms to Betsey and puts her to use in the Fly Room, counting and characterizing flies. He becomes so comfortable having his daughter around that he neglects to hide his after-hours philandering.

Much of the film unfolds in the Fly Room. The set designers have paid close attention to detail: for example, the microscopes are the binocular version that Bridges invented.

Bridges left his family; Morgan moved his lab to the California Institute of Technology and Bridges joined him. The Fly Room makes no attempt to provide an authoritative history, leaving many details to the epilogue. In an interview, 95-year-old Betsey says that she never wanted to be like her dad. An apt sentiment about a father who was flawed — but who laid the groundwork for the modern science of heredity.

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