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  Most biological functions are carried out by proteins encoded in the genome, and to understand how a cell or an organism work, one must study what proteins are present, how they interact with each other and what they do. Proteomics research aims to understand protein content and function at a global level, and thereby promises to transform biological and medical research. Here, Nature presents a special web focus, containing a series of free reviews outlining the progress made and future challenges in this technology-driven enterprise, as well as an archive of research news and features on proteomics from Nature, Nature Genetics and Nature Biotechnology.



From genomics to proteomics
M Tyers & M Mann

Mass spectrometry-based proteomics
R Aebersold & M Mann

Protein analysis on a proteomic scale
E Phizicky, P I H Bastiaens, H Zhu, M Snyder & S Fields

From words to literature in structural proteomics
A. Sali, R. Glaeser, T. Earnest & W. Baumeister

Disease proteomics
S. Hanash

Biomedical informatics for proteomics
M S Boguski & M W McIntosh


Constellations in the cellular universe
R. Aebersold



NEWS & FEATURES
Proteomics: The society of proteins
Alison Abbott
Having realized that proteins usually do their jobs by combining to form transient complexes, biologists are queuing up to study these structures using a powerful electron-microscopy technique. Alison Abbott reports.
Nature 417, 894 - 896 (27 Jun 2002)

RESEARCH
A proteomic view of the Plasmodium falciparum life cycle
Laurence Florens et al.
Nature 419, 520 - 526 (03 Oct 2002)

Comprehensive proteomic analysis of the human spliceosome
Zhaolan Zhou, Lawrence J. Licklider, Steven P. Gygi, Robin Reed
Nature 419, 182 - 185 (12 Sep 2002)

Functional organization of the yeast proteome by systematic analysis of protein complexes
Anne-Claude Gavin et al.
Nature 415, 141 - 147 (10 Jan 2002)

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
Peter Uetz et al.
Nature 403, 623 - 627 (10 Feb 2000)

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Yuen Ho, et al.
Nature 415, 180 - 183 (10 Jan 2002)

The protein-protein interaction map of Helicobacter pylori
Jean-Christophe Rain et al.
Nature 409, 211 - 215 (11 Jan 2001)

The study of macromolecular complexes by quantitative proteomics
Jeffrey A. Ranish et al.
Nature Genetics 33, 349 - 355 (01 Mar 2003)

A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
Blagoy Blagoev et al.
Nature Biotechnology 21, 315 - 318 (01 Mar 2003)

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