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  Boy meets girl, sperm meets egg. This timeless tale is increasingly being played out in a culture dish, such is the progress in germ cell biology in recent times. Here, Nature presents the latest research on the establishment of the germline, and a special feature on the biologists who are trying to grow germ cells in the lab, but face the technical and ethical minefield as a result. Also featured is an archivefrom Nature and other Nature Research journals.
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Synthetic sex cells
Some pioneering biologists are trying to grow eggs and sperm in the lab. In doing so, they're entering a technical and ethical minefield. Carina Dennis reports
Nature 424, 364 - 366 (24 July 2003)





Exclusions of germ plasm proteins from somatic lineages by cullin-dependent degradation
Cynthia DeRenzo, Kimberly J. Reese and Geraldine Seydoux
Nature AOP, published online (23 July 2003)



DNA re-write could allay cloning fears
Extra step might overcome safety objections to reproductive cloning.

Eggs made from embryos
Reprogramming step towards safer reproductive cloning.

A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor
Holger Knaut, Christian Werz, Robert Geisler, The Tübingen 2000 Screen Consortium The Tübingen 2000 Screen Consortium, Christiane Nüsslein-Volhard
Nature 421, 279 - 282 (16 Jan 2003)

Developmental biology: Germ-cell attraction
Prabhat S. Kunwar, Ruth Lehmann
Nature 421, 226 - 227 (16 Jan 2003)

Border-cell migration: the race is on
Denise J. Montell
Nature Reviews Molecular Cell Biology 4, 13 - 24 (01 Jan 2003)

Human genetics and disease: Mouse models of male infertility
Howard J. Cooke, Philippa T. K. Saunders
Nature Reviews Genetics 3, 790 - 801 (01 Oct 2002)

Sperm from neonatal mammalian testes grafted in mice
Ali Honaramooz, Amy Snedaker, Michele Boiani, Hans Schöler, Ina Dobrinski, Stefan Schlatt
Nature 418, 778 - 781 (15 Aug 2002)

Oogenesis: Maturation of mouse fetal germ cells in vitro
Yayoi Obata, Tomohiro Kono, Izuho Hatada
Nature 418, 497 (01 Aug 2002)

A molecular programme for the specification of germ cell fate in mice
Mitinori Saitou, Sheila C. Barton, M. Azim Surani
Nature 418, 293 - 300 (18 Jul 2002)

Developmental biology: Decisions, decisions!
Brigid Hogan
Nature 418, 282 - 283 (18 Jul 2002)

A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans
Sarah L. Crittenden, David S. Bernstein, Jennifer L. Bachorik, Beth E. Thompson, Maria Gallegos, Andrei G. Petcherski, Gary Moulder, Robert Barstead, Marvin Wickens, Judith Kimble
Nature 417, 660 - 663 (06 Jun 2002)

Commuting the death sentence: How oocytes strive to survive
Jonathan L. Tilly
Nature Reviews Molecular Cell Biology 2, 838 - 848 (01 Nov 2001)

Somatic control over the germline stem cell lineage during Drosophila spermatogenesis
John Tran, Tamara J. Brenner, Stephen DiNardo
Nature 407, 754 - 757 (12 Oct 2000)

The LIM homeobox gene Lhx9 is essential for mouse gonad formation
Ohad S. Birk et al.
Nature 403, 909 - 913 (24 Feb 2000)

Mitochondria and germ-cell death
David C. Krakauer, Alex Mira
Nature 400, 125 - 126 (08 Jul 1999)

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
Qingxian Lu et al.
Nature 398, 723 - 728 (22 Apr 1999)

Reproduction: Germ cells colonized by endosymbiotic bacteria
Stephen J. Hadfield, J. Myles Axton
Nature 402, 482 (02 Dec 1999)

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