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Wu et al. explore vaccine strategies targeting age-related diseases, as well as senescent cells specifically, as potential underlying drivers of aging itself. They discuss challenges faced in clinical trials, as well as further optimizations required to increase therapeutic efficacy.
Tissue mosaicism, driven by somatically acquired changes, is an emerging hallmark of aging. This Review coalesces recent discoveries from the hematopoietic system to integrate this phenomenon into the current framework of stem cell aging.
de Luzy et al. review recent work exploring the induction and functional consequences of neuronal senescence in aging and neurodegenerative disease, and discuss the potential of modeling neuronal senescence with pluripotent stem cell models.
