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The cover shows a fluorescent microscopic image of a precision cut lung section with CD103+ dendritic cells (red), SIRP-1a+ dendritic cells and alveolar macrophages (magenta), and E-cadherin+ epithelial cells (green). Thomas et al., found that MyD88 gene expression in lung dendritic cells is controlled by cellintrinsic and -extrinsic MyD88 signaling, and that these different signals orchestrate immune responses to inhaled allergens. Image was provided by Seddon Y. Thomas, Miranda R. Lyons-Cohen, and Donald N. Cook, Immunity, Inflammation, and Disease Laboratory, NIEHS, NIH. For more information, please see the manuscript in this issue, see the article on page 796.