Dunlap and colleagues describe a novel role for chemokine receptor CCR2 in the migration of alveolar macrophages out of the airways and into tuberculous granulomas during infection with M. tuberculosis. After airway adoptive transfer, alveolar macrophages expressing CCR2 (green) and Siglec F+ (Red) localized within tuberculosis granulomas in a CCR2 dependent manner, demonstrating a previously unknown mechanism of host defense against Mycobacterium tuberculosis. For further information see article in this issue, page 1727. Image Courtesy of Javier Rangel-Moreno, Micah D. Dunlap, and Shabaana A. Khader.

The cover shows a fluorescent microscopic image of a precision cut lung section with CD103+ dendritic cells (red), SIRP-1a+ dendritic cells and alveolar macrophages (magenta), and E-cadherin+ epithelial cells (green). Thomas et al., found that MyD88 gene expression in lung dendritic cells is controlled by cellintrinsic and -extrinsic MyD88 signaling, and that these different signals orchestrate immune responses to inhaled allergens. Image was provided by Seddon Y. Thomas, Miranda R. Lyons-Cohen, and Donald N. Cook, Immunity, Inflammation, and Disease Laboratory, NIEHS, NIH. For more information, please see the manuscript in this issue, see the article on page 796.