The checkpoint pathway consisting of programmed death ligand 1 (PD-L1) and its receptor, PD-1, modulates immune function in cancer and infection, but unexpectedly, it also silences pain signals in nerves.
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Hirth, M., Gandla, J. & Kuner, R. A checkpoint to pain. Nat Neurosci 20, 897–899 (2017). https://doi.org/10.1038/nn.4586
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DOI: https://doi.org/10.1038/nn.4586
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