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Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress

Journal of Exposure Science & Environmental Epidemiology volume 27, pages 244–250 (2017)Cite this article

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Abstract

Using data collected before, during, and after the 2008 Summer Olympic Games in Beijing, this study examines associations between biomarkers of blood coagulation (vWF, sCD62P and sCD40L), pulmonary inflammation (EBC pH, EBC nitrite, and eNO), and systemic oxidative stress (urinary 8-OHdG) with sources of air pollution identified utilizing principal component analysis and with concentrations of three aldehydes of health concern. Associations between the biomarkers and the air pollution source types and aldehydes were examined using a linear mixed effects model, regressing through seven lag days and controlling for ambient temperature, relative humidity, gender, and day of week for the biomarker measurements. The biomarkers for pulmonary inflammation, particularly EBC pH and eNO, were most consistently associated with vehicle and industrial combustion, oil combustion, and vegetative burning. The biomarkers for blood coagulation, particularly vWF and sCD62p, were most consistently associated with oil combustion. Systemic oxidative stress biomarker (8-OHdG) was most consistently associated with vehicle and industrial combustion. The associations of the biomarkers were generally not significant or consistent with secondary formation of pollutants and with the aldehydes. The findings support policies to control anthropogenic pollution sources rather than natural soil or road dust from a cardio-respiratory health standpoint.

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Acknowledgements

We thank the HEART study team for their effort in sample and data collection and previous data analyses. The HEART study was originally funded in part by a grant from HEI (#4760-RPFA05-3) and a grant from NIEHS (#1R01 ES0158640), as well NIEHS P30 Center Grant ES005022. Dr. Zhu was partly funded by Beijing EPA (OITC-G08026056). However, the opinions expressed in this manuscript are solely of the authors and do not necessarily reflects those of the funding agencies.

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Authors and Affiliations

  1. School of Public Health, Rutgers University, Piscataway, New Jersey, USA

    Brent Altemose, Pamela Ohman Strickland & Qingyu Meng

  2. School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, USA

    Mark G Robson

  3. Environmental and Occupational Sciences Institute (EOHSI), Rutgers University, Piscataway, New Jersey, USA

    Howard M Kipen

  4. Nicholas School of the Environment and Duke Global Health Institute, Duke University, Durham, North Carolina, USA

    Jicheng Gong & Junfeng Zhang

  5. Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China

    Jicheng Gong & Junfeng Zhang

  6. State Key Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, China

    Wei Huang & Tong Zhu

  7. Department of Pulmonary Medicine, Peking University First Hospital, Beijing, China

    Guangfa Wang

  8. Department of Public Health Sciences, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA

    David Q Rich

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  1. Brent Altemose
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  2. Mark G Robson
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Correspondence to Junfeng Zhang.

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Altemose, B., Robson, M., Kipen, H. et al. Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. J Expo Sci Environ Epidemiol 27, 244–250 (2017). https://doi.org/10.1038/jes.2016.38

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