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Fangjiomics in Traditional Chinese Medicine: Progress and Perspective
In the traditional Chinese medicine (TCM), diseases are treated with a combination of herbs (Fangji) according to the Jun-Chen-Zuo-Shi principle for well-defined roles of targeting major and minor problems. While the empirical Fangji therapy of disease has been proven clinically effective the underlying mechanisms for the combined targets remain mysteries. Fangjiomics systematically studies myriad compatible combinations that act through multiple targets and balance on- and off-targets. By prioritizing targets, Fangjiomics addresses the key components and issues in combination therapies and may lead to novel controllable array-designed therapies to combine less potent elements with more on-target and fewer off-target effects. This forthcoming Special Issue of Acta Pharmacologica Sinica assembles a series of updated omic studies on several famous Fangjis from view of systems biology and network pharmacology.
Original Articles
Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach
Zhen-zhong Yang, Wei Liu, Feng Zhang, Zheng Li & Yi-yu Cheng
Acta Pharmacologica Sinica 36: 699–707; doi:10.1038/aps.2014.138
Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis
Hui-qin Li1, Jing-jing Wei1, Wan Xia, Ji-huang Li, Ai-ju Liu, Su-bing Yin, Chen Wang, Liang Song, Yan Wang, Guo-qing Zheng & Ji-ping Fan
Acta Pharmacologica Sinica 36: 659–675; doi:10.1038/aps.2014.139
Multiscale Modeling of Drug-induced Effects of ReDuNing Injection on Human Disease: From Drug Molecules to Clinical Symptoms of Disease
Fang Luo, Jiangyong Gu, Xinzhuang Zhang, Lirong Chen, Liang Cao, Na Li, Zhenzhong Wang, Wei Xiao & Xiaojie Xu
Scientific Reports 5: 10064; doi:10.1038/srep10064
Network Understanding of Herb Medicine via Rapid Identification of Ingredient-Target Interactions
Hai-Ping Zhang,Jian-Bo Pan,Chi Zhang,Nan Ji,Hao Wang & Zhi-Liang Ji
Scientific Reports 4: 3719; doi:10.1038/srep03719
Uncovering pharmacological mechanisms of Wu-tou decoction acting on rheumatoid arthritis through systems approaches: drug-target prediction, network analysis & experimental validation
Yanqiong Zhang, Ming Bai,Bo Zhang,Chunfang Liu,Qiuyan Guo,Yanqun Sun,Danhua Wang,Chao Wang,Yini Jiang,Na Lin & Shao Li
Scientific Reports 5: 9463; doi:10.1038/srep09463
Reviews
Diverse array-designed modes of combination therapies in Fangjiomics
Jun Liu & Zhong Wang
Acta Pharmacologica Sinica 36: 680–688; doi:10.1038/aps.2014.125
Network pharmacology: the next paradigm in drug discovery
Andrew L Hopkins
Nature Chemical Biology 4: 682–690; doi:10.1038/nchembio.118
Network medicine: a network-based approach to human disease
Albert-LószlÓ Barabási, Natali Gulbahce, & Joseph Loscalzo
Nature Reviews Genetics 12: 56–68; doi:10.1038/nrg2918
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