Genomic instability and cancer
- Submission status
- Open
- Submission deadline
Genomic instability is characterized by a high frequency of genetic mutations and can manifest as chromosomal copy number aberrations, rearrangements, or smaller alterations. Genomic instability can have pathogenic effects in cancer, and understanding the underlying causes of genomic instability is necessary for developing strategies to reduce and reverse these effects. Additionally, because genomic instability is a characteristic of cancer cells, it is an attractive therapeutic target for anticancer therapy.
This Collection invites original research into genomic instability in cancer, from basic research assessing the underlying mechanisms to preclinical and clinical studies targeting genomic instability.
Editors
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Xingzhi Xu, PhD, Professor
Shenzhen University Medical School, China
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Yasunaga Yoshikawa, DVM, PhD
Kitasato University, Japan
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Ken-ichi Yoshioka, PhD
National Cancer Center Research Institute, Japan
Xingzhi Xu, PhD, Professor, Shenzhen University Medical School, China
Xingzhi Xu is the Vice Dean of Shenzhen University Medical School. His long-standing research interests fall in molecular mechanisms of DNA damage response, DNA replication stress response and associated diseases including cancer, and development of anti-cancer lead compounds targeting genome stability. Dr Xu has been an Editorial Board Member for Scientific Reports since 2024.
Yasunaga Yoshikawa, DVM, PhD, Kitasato University, Japan
Yasunaga Yoshikawa is an Associate Professor at School of Veterinary Medicine, Kitasato University, Japan. His research activities include the DNA repair, especially in FA/BRCA pathway and molecular oncology using cultured cell lines and animals. Dr. Yoshikawa has been working as an Editorial Board Member for Scientific Reports since 2024.
Ken-ichi Yoshioka, PhD, National Cancer Center Research Institute, Japan
Ken-ichi Yoshioka is the Laboratory Head of the Laboratory of Genome Stability Maintenance, National Cancer Center Research Institute, Tokyo, Japan. His research focuses on cancer-associated genomic instability events, including the chromatin state risking genomic instability and the effects of genomic instability on therapy. Dr Yoshioka has been an Editorial Board Member for Scientific Reports since 2024.
