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Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder

The Pharmacogenomics Journal volume 13, pages 354–358 (2013)Cite this article

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Abstract

Association between response to antidepressant treatment and genetic polymorphisms was examined in two independent Japanese samples of patients with major depressive disorder (MDD). Genome-wide approach using the Illumina Human CNV370-quad Bead Chip was utilized in the analysis of the 92 MDD patients in the first sample. In all, 11 non-intergenic single-nucleotide polymorphisms with uncorrected allelic P-value <0.0001 were selected for the subsequent association analyses in the second sample of 136 MDD patients. Difference in allele distribution between responders and nonresponders were found in the second-stage sample for rs365836 and rs201522 of the CUX1 gene (P=0.005 and 0.004, respectively). The allelic P-values for rs365836 and rs201522 in both samples combined were 0.0000023 and 0.0000040, respectively. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD.

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Acknowledgements

This study was supported by Intramural Research Grant (21-9) for Neurological and Psychiatric Disorders of NCNP, CREST by JST (Creation of a Novel Technology towards Diagnosis and Treatment based on Understanding of Molecular Pathogenesis of Psychiatric and Neurological Disorders), and the Strategic Research Program (Understanding of molecular and environmental bases for brain health) for Brain Sciences by the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

    D Sasayama, A Hiraishi & H Kunugi

  2. Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Japan

    D Sasayama

  3. Yokohama Shinryo Clinic, Yokohama, Japan

    M Tatsumi

  4. International University of Health and Welfare, Otawara, Tochigi, Japan

    K Kamijima

  5. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

    M Ikeda & N Iwata

  6. Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan

    W Umene-Nakano, R Yoshimura & J Nakamura

  7. Core Research of Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo, Japan

    H Kunugi

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  1. D Sasayama
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Correspondence to H Kunugi.

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Sasayama, D., Hiraishi, A., Tatsumi, M. et al. Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder. Pharmacogenomics J 13, 354–358 (2013). https://doi.org/10.1038/tpj.2012.18

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  • DOI: https://doi.org/10.1038/tpj.2012.18

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