A recent publication in Nature Aging suggests that DOPA decarboxylase may serve as an emerging biomarker that can identify neurodegenerative disorders that are characterized by dopaminergic cell loss. Here we discuss how this finding can assist clinicians and researchers in the differential diagnosis of individuals who present with parkinsonism or cognitive decline.
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References
Bloem, B. R., Okun, M. S. & Klein, C. Lancet 397, 2284–2303 (2021).
Beach, T. G. & Adler, C. H. Mov. Disord. 33, 1551–1554 (2018).
Pereira, J. B. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00478-y (2023).
Xiang, C. et al. NPJ Parkinsons Dis. 8, 165 (2022).
Siderowf, A. et al. Lancet Neurol. 22, 407–417 (2023).
van Rumund, A. et al. Ann. Neurol. 85, 777–781 (2019).
Poggiolini, I. et al. Brain 145, 584–595 (2022).
Shahnawaz, M. et al. Nature 578, 273–277 (2020).
Quadalti, C. et al. NPJ Parkinsons Dis. 7, 93 (2021).
Marques, T. M. et al. Neurology 92, e1479–e1486 (2019).
Chahine, L. M. et al. J. Parkinsons Dis. 13, 297–309 (2023).
van Rumund, A. et al. NPJ Parkinsons Dis. 7, 29 (2021).
Beckers, M., Bloem, B. R. & Verbeek, M. M. NPJ Parkinsons Dis. 8, 56 (2022).
Rojo-Sebastián, A., González-Robles, C. & García de Yébenes, J. Clin. Neuropharmacol. 43, 151–157 (2020).
Aerts, M. B. et al. J. Neurol. 262, 346–356 (2015).
Acknowledgements
The Radboudumc Centre of Expertise for Parkinson & Movement Disorders was supported by a center of excellence grant by the Parkinson’s Foundation. M.M.V. and B.R.B. are supported by grants from Stichting Alkemade-Keuls, ParkinsonNL (project P2021-18), the Maag Lever Darm Stichting (project WOO 21-05), the ‘Stichting Woelse Waard’, the Dutch Brain Foundation (MADAM project) and ZonMW (MIGUT project, 09120012110098).
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Verbeek, M.M., Bloem, B.R. An emerging biomarker for dopaminergic cell loss. Nat Aging 3, 1180–1182 (2023). https://doi.org/10.1038/s43587-023-00501-2
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DOI: https://doi.org/10.1038/s43587-023-00501-2