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FOXM1 delays senescence and extends lifespan

Nature Aging volume 2, pages 373–374 (2022)Cite this article

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Aging is accompanied by a gradual decline of cell proliferation potential. FOXM1 is a transcription factor involved in cellular proliferation and cell cycle progression. Ribeiro et al. show that cyclic expression of a truncated form of a FOXM1 transgene in vivo can delay senescence-associated progeroid and natural aging phenotypes in mice.

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Fig. 1: Cyclic expression of N-terminally truncated FOXM1 improves health and lifespan.

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Authors and Affiliations

  1. Department of Regenerative Medicine, Chiba University Graduate School of Medicine, Chiba, Japan

    Yasuo Ouchi

  2. Salk Institute for Biological Studies, La Jolla, CA, USA

    Yasuo Ouchi

  3. Altos Labs, San Diego, CA, USA

    Sanjeeb Kumar Sahu & Juan Carlos Izpisua Belmonte

Authors
  1. Yasuo Ouchi
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  2. Sanjeeb Kumar Sahu
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  3. Juan Carlos Izpisua Belmonte
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Correspondence to Juan Carlos Izpisua Belmonte.

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The authors declare no competing interests.

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Ouchi, Y., Sahu, S.K. & Izpisua Belmonte, J.C. FOXM1 delays senescence and extends lifespan. Nat Aging 2, 373–374 (2022). https://doi.org/10.1038/s43587-022-00222-y

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