In this issue of Nature Metabolism, the research team of Mitchell Lazar reveals unexpected consequences of double loss of the coregulators NCOR1 and NCOR2 (NCOR1/2) in hepatocytes of adult mice, which affects chromatin functioning and glucocorticoid receptor (GR)-mediated gene transcription.
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Acknowledgements
The authors receive research support from VIB (KadBo), the Research Foundation Flanders (FWO) (G0A5124N) and UGent BOF/24J/2021/374.
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Van Leene, C., De Bosscher, K. NCOR1/2 and glucocorticoid receptor orchestrate hepatic function. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01028-5
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DOI: https://doi.org/10.1038/s42255-024-01028-5