Metabolism

Definition

Metabolism refers to the chemical reactions that occur within an organism to sustain life. The reactions are divided into two categories: catabolism (the breakdown of organic matter to produce energy); and anabolism (the construction of molecules from smaller units).

Latest Research and Reviews

  • Reviews |

    Thirst is a homeostatic response to changes in fluid balance and is governed by a set of interconnected brain structures known as the lamina terminalis. In this Progress article, Knight and colleagues summarize recent updates to our understanding of the neural circuitry underlying thirst and drinking behaviour in mammals.

    • Christopher A. Zimmerman
    • , David E. Leib
    •  & Zachary A. Knight
  • Research |

    Ban et al. show that optic atrophy 1 (OPA1) and cardiolipin mediate mitochondrial fusion. In contrast, a homotypic trans-OPA1 interaction independent of cardiolipin mediates membrane tethering to form mitochondrial cristae.

    • Tadato Ban
    • , Takaya Ishihara
    • , Hiroto Kohno
    • , Shotaro Saita
    • , Ayaka Ichimura
    • , Katsumi Maenaka
    • , Toshihiko Oka
    • , Katsuyoshi Mihara
    •  & Naotada Ishihara
  • Research |

    The precise mechanisms that cause human obesity remain unknown. Here the authors illustrate how increased expression of Cadm1, a mediator of synapse assembly, is relevant to weight gain. Reduction of Cadm1 in multiple brain regions promoted weight loss, and these observations provide insight into the neuronal pathways contributing to obesity.

    • Thomas Rathjen
    • , Xin Yan
    • , Natalia L Kononenko
    • , Min-Chi Ku
    • , Kun Song
    • , Leiron Ferrarese
    • , Valentina Tarallo
    • , Dmytro Puchkov
    • , Gaga Kochlamazashvili
    • , Sebastian Brachs
    • , Luis Varela
    • , Klara Szigeti-Buck
    • , Chun-Xia Yi
    • , Sonja C Schriever
    • , Sudhir Gopal Tattikota
    • , Anne Sophie Carlo
    • , Mirko Moroni
    • , Jan Siemens
    • , Arnd Heuser
    • , Louise van der Weyden
    • , Andreas L Birkenfeld
    • , Thoralf Niendorf
    • , James F A Poulet
    • , Tamas L Horvath
    • , Matthias H Tschöp
    • , Matthias Heinig
    • , Mirko Trajkovski
    • , Volker Haucke
    •  & Matthew N Poy
  • Research |

    Composition of gut bacteria and serum metabolites in young, obese individuals is partially restored following weight loss surgery, including Bacteroides thetaiotaomicron, which decreases serum glutamate levels and fat mass gain in mice.

    • Ruixin Liu
    • , Jie Hong
    • , Xiaoqiang Xu
    • , Qiang Feng
    • , Dongya Zhang
    • , Yanyun Gu
    • , Juan Shi
    • , Shaoqian Zhao
    • , Wen Liu
    • , Xiaokai Wang
    • , Huihua Xia
    • , Zhipeng Liu
    • , Bin Cui
    • , Peiwen Liang
    • , Liuqing Xi
    • , Jiabin Jin
    • , Xiayang Ying
    • , Xiaolin Wang
    • , Xinjie Zhao
    • , Wanyu Li
    • , Huijue Jia
    • , Zhou Lan
    • , Fengyu Li
    • , Rui Wang
    • , Yingkai Sun
    • , Minglan Yang
    • , Yuxin Shen
    • , Zhuye Jie
    • , Junhua Li
    • , Xiaomin Chen
    • , Huanzi Zhong
    • , Hailiang Xie
    • , Yifei Zhang
    • , Weiqiong Gu
    • , Xiaxing Deng
    • , Baiyong Shen
    • , Xun Xu
    • , Huanming Yang
    • , Guowang Xu
    • , Yufang Bi
    • , Shenghan Lai
    • , Jian Wang
    • , Lu Qi
    • , Lise Madsen
    • , Jiqiu Wang
    • , Guang Ning
    • , Karsten Kristiansen
    •  & Weiqing Wang

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