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Lipid metabolism

mTORC1 takes control of lysosomal lipid breakdown

Nature Metabolism volume 4, pages 1620–1622 (2022)Cite this article

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mTORC1 integrates environmental signals to promote anabolism and repress catabolism. In this issue of Nature Metabolism, Hosios et al. identify a role for mTORC1 in controlling endosomal trafficking and degradation of membrane phospholipids in the lysosome, revealing a novel process used by cells to adapt to poor growth conditions.

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Fig. 1: mTORC1 inhibition promotes membrane phospholipid delivery and degradation in the lysosome.

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Acknowledgements

M.L. is supported by the Canadian Institutes of Health Research (CIHR) (374552 and 419593), Les Fonds de Recherche du Québec-Santé (FRQS)(312374), La Fondation de l’Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval (IUCPQ-UL), the Natural Sciences and Engineering Research Council of Canada (NSERC) (2019-06497) and Le Réseau de recherche sur la santé cardiométabolique, le diabète et l’obésité (CMDO). L.T. is supported by a fellowship from Diabète Bas-Saint-Laurent.

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  1. Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Québec City, Québec, G1V 4G5, Canada

    Laura Tribouillard & Mathieu Laplante

  2. Centre de recherche sur le cancer de l’Université Laval, Université Laval, Québec City, Québec, Canada

    Laura Tribouillard & Mathieu Laplante

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  1. Laura Tribouillard
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  2. Mathieu Laplante
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Correspondence to Mathieu Laplante.

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Tribouillard, L., Laplante, M. mTORC1 takes control of lysosomal lipid breakdown. Nat Metab 4, 1620–1622 (2022). https://doi.org/10.1038/s42255-022-00702-w

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