TOR signalling

Definition

TOR (target of rapamycin) signalling is a cell signalling pathway. TOR and its mammalian ortholog mTOR are serine-threonine kinases that sense growth factor, nutrient or oxygen status and promote appropriate changes in cell growth and proliferation, cell survival, and protein synthesis. TOR signalling has key roles in cancer and autophagy.

Latest Research and Reviews

  • Research |

    Two papers by Liu et al. and Ansó et al. study the post-transcriptional regulation of mitochondrial factors in erythropoiesis and the role of RISP-mediated mitochondrial respiration in fetal and adult HSC function via metabolites and epigenetic changes.

    • Xin Liu
    • , Yuannyu Zhang
    • , Min Ni
    • , Hui Cao
    • , Robert A. J. Signer
    • , Dan Li
    • , Mushan Li
    • , Zhimin Gu
    • , Zeping Hu
    • , Kathryn E. Dickerson
    • , Samuel E. Weinberg
    • , Navdeep S. Chandel
    • , Ralph J. DeBerardinis
    • , Feng Zhou
    • , Zhen Shao
    •  & Jian Xu
  • Research |

    Ubiquitination of the GβL subunit, a component of both mTORC1 and mTORC2, acts as a regulatory switching mechanism to balance levels of mTORC1 and mTORC2; the failure of this mechanism in some cancers leads to elevated mTORC2 formation and tumorigenesis.

    • Bin Wang
    • , Zuliang Jie
    • , Donghyun Joo
    • , Alban Ordureau
    • , Pengda Liu
    • , Wenjian Gan
    • , Jianping Guo
    • , Jinfang Zhang
    • , Brian J. North
    • , Xiangpeng Dai
    • , Xuhong Cheng
    • , Xiuwu Bian
    • , Lingqiang Zhang
    • , J. Wade Harper
    • , Shao-Cong Sun
    •  & Wenyi Wei
    Nature 545, 365–369
  • Research | | open

    In response to gut epithelial damage, Drosophila stem cells proliferate to produce large polyploid enterocytes (EC), which comprise the bulk of the epithelium. Here, the authors show that stress-dependent EGFR/MAP kinase signalling drives both endoreplication and cell growth in newborn ECs.

    • Jinyi Xiang
    • , Jennifer Bandura
    • , Peng Zhang
    • , Yinhua Jin
    • , Hanna Reuter
    •  & Bruce A. Edgar
  • Research |

    A protein complex composed of KPTN, ITFG2, C12orf66 and SZT2, named KICSTOR, is necessary for lysosomal localization of GATOR1, interaction of GATOR1 with the Rag GTPases and GATOR2, and nutrient-dependent mTORC1 modulation.

    • Rachel L. Wolfson
    • , Lynne Chantranupong
    • , Gregory A. Wyant
    • , Xin Gu
    • , Jose M. Orozco
    • , Kuang Shen
    • , Kendall J. Condon
    • , Sabrina Petri
    • , Jibril Kedir
    • , Sonia M. Scaria
    • , Monther Abu-Remaileh
    • , Wayne N. Frankel
    •  & David M. Sabatini
    Nature 543, 438–442
  • Research | | open

    Inhibitors of the mTORC1 pathway are considered anti-cancer drugs. Here, the authors show that on nutrient restriction, glutaminolysis-induced activation of mTORC1 induces apoptosis via inhibiting autophagy, highlighting that under such conditions inhibition of mTORC1 results in survival of cancer cells.

    • Victor H. Villar
    • , Tra Ly Nguyen
    • , Vanessa Delcroix
    • , Silvia Terés
    • , Marion Bouchecareilh
    • , Bénédicte Salin
    • , Clément Bodineau
    • , Pierre Vacher
    • , Muriel Priault
    • , Pierre Soubeyran
    •  & Raúl V. Durán

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