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Inflammation

Pas de deux of NLRP3 and ASC with CD63 on mast cell granules

Nature Immunology volume 25, pages 584–586 (2024)Cite this article

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Granulosomes are novel complexes that feature an unexpected partnership between the tetraspanin CD63 and the inflammasome proteins NLRP3 and ASC. Granulosomes assemble on mast cell granules to propel them along microtubules to the plasma membrane for degranulation.

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Fig. 1: Granulosomes take center stage in MC degranulation.

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Acknowledgements

J.M.B. and her lab are supported by National Institutes of Health (NIH) grants AI170832, AI170897 and AI178327, a grant (project 2021299) from the US–Israel Binational Science Foundation, and by the Smart Foundation.

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Authors and Affiliations

  1. Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA

    J. Magarian Blander & Yuhua Shi

  2. Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY, USA

    J. Magarian Blander & Yuhua Shi

  3. Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY, USA

    J. Magarian Blander

  4. Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, Cornell University, New York, NY, USA

    J. Magarian Blander

  5. Immunology and Microbial Pathogenesis Programs, Weill Cornell and Sloan Kettering Institute Graduate School of Medical Sciences, New York, NY, USA

    J. Magarian Blander

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  1. J. Magarian Blander
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  2. Yuhua Shi
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Correspondence to J. Magarian Blander.

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Blander, J.M., Shi, Y. Pas de deux of NLRP3 and ASC with CD63 on mast cell granules. Nat Immunol 25, 584–586 (2024). https://doi.org/10.1038/s41590-024-01791-3

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