Antibodies

Definition

Antibodies are secreted immunoglobulin molecules produced mainly by plasma cells. The antigen-binding site of the antibody has a unique structure that allows it to bind antigen in a highly specific manner.

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News and Comment

  • News and Views |

    HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.

    • Georg A. Böhmig
    •  & Lionel Rostaing
  • Research Highlights |

    Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell–B cell collaboration for antibody production.

    • Jonathan Sprent
  • News and Views |

    M cells sample gut lumenal antigens and microbes to induce gut immune responses. A novel population of stromal cell—the M cell inducers—are essential for sustaining M cell differentiation and bacteria-specific production of immunoglobulin A to maintain the gut–immune system symbiosis.

    • Gabrielle T Belz
    •  & Francisca F Almeida
    Nature Immunology 18, 601–602
  • News and Views |

    Antibodies to neutralizing epitopes on hemagglutinin exhibit reproducible dynamic immunodominance patterns over time. Early responses target largely the Cb site, followed by Sb dominance and a concomitant rise in the diversity of neutralizing-antibody specificities.

    • Gordon A Dale
    • , Jessica R Shartouny
    •  & Joshy Jacob
    Nature Immunology 18, 367–368