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Stromal immunology

New fibroblast network connections support lymphocytic cellular service

Single-cell RNA sequencing distinguishes subsets of fibroblastic reticular cells and predicts pathways that support immune function via crosstalk with lymphocytes.

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Fig. 1: Heterogeneity of fibroblastic reticular cells in secondary lymphoid organs in humans and mice.

References

  1. Fletcher, A. L., Baker, A. T., Lukacs-Kornek, V. & Knoblich, K. Curr. Opin. Immunol. 64, 110–116 (2020).

    Article  CAS  PubMed  Google Scholar 

  2. Lütge, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01503-3 (2023).

    Article  PubMed  Google Scholar 

  3. De Martin, A. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01502-4 (2023).

    Article  PubMed  Google Scholar 

  4. Good-Jacobson, K. L. Immunol. Rev. 284, 67–78 (2018).

    Article  CAS  PubMed  Google Scholar 

  5. Denton, A. E. et al. J. Exp. Med. 216, 621–637 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ansel, K. M. et al. Nature 406, 309–314 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. Buechler, M. B. et al. Nature 593, 575–579 (2021).

    Article  CAS  PubMed  Google Scholar 

  8. Siegert, S. et al. PLoS ONE 6, e27618 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lukacs-Kornek, V. et al. Nat. Immunol. 12, 1096–1104 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Knoblich, K. et al. PLoS Biol. 16, e2005046 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Duan, L. et al. Immunity 54, 2256–2272 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Papillion, A. et al. Sci. Immunol. 4, eaaw7636 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Anne L. Fletcher or Kim L. Good-Jacobson.

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Competing interests

A.F. is a consultant and member of the scientific advisory board of Phenomic AI. K.L.G.-J. declares no competing interests.

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Fletcher, A.L., Good-Jacobson, K.L. New fibroblast network connections support lymphocytic cellular service. Nat Immunol 24, 1054–1055 (2023). https://doi.org/10.1038/s41590-023-01537-7

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