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100 years of antibody solitude in TB

Analysis of antibody responses in BCG intravenous vaccination against Mycobacterium tuberculosis in non-human primates show a potential protective role for IgM.

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Fig. 1: Potential mechanisms of humoral immunity in host defense against Mycobacterium tuberculosis.

References

  1. Barclay, W. R., Anacker, R. L., Brehmer, W., Leif, W. & Ribi, E. Infect. Immun. 2, 574–582 (1970).

    Article  CAS  Google Scholar 

  2. Darrah, P. A. et al. Nature 577, 95–102 (2020).

    Article  CAS  Google Scholar 

  3. Irvine, E. B. Nat. Immunol. https://doi.org/10.1038/10.1038/s41590-021-01066-1 (2021).

  4. Li, H. & Javid, B. Nat. Rev. Immunol. 18, 591–596 (2018).

    Article  CAS  Google Scholar 

  5. Costello, A. M. et al. Trans. R. Soc. Trop. Med. Hyg. 86, 686–692 (1992).

    Article  CAS  Google Scholar 

  6. de Valliere, S., Abate, G., Blazevic, A., Heuertz, R. M. & Hoft, D. F. Infect. Immun. 73, 6711–6720 (2005).

    Article  Google Scholar 

  7. Encinales, L. et al. Mol. Immunol. 47, 1066–1073 (2010).

    Article  CAS  Google Scholar 

  8. Cohen, S. B. et al. Cell Host Microbe 24, 439–446.e434 (2018).

    Article  CAS  Google Scholar 

  9. Kaufmann, E. et al. Cell 172, 176–190.e119 (2018).

    Article  CAS  Google Scholar 

  10. Khan, N. et al. Cell 183, 752–770.e722 (2020).

    Article  CAS  Google Scholar 

  11. Dan, J. M. et al. Science 371, eabf4063 (2021).

    Article  CAS  Google Scholar 

  12. Watson, A. et al. Nat. Commun. 12, 602 (2021).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Maziar Divangahi.

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Divangahi, M., Javid, B. & Kaufmann, E. 100 years of antibody solitude in TB. Nat Immunol 22, 1470–1471 (2021). https://doi.org/10.1038/s41590-021-01071-4

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