Tuberculosis

Definition

Tuberculosis (TB) is an infectious disease caused by strains of bacteria known as mycobacteria. The disease most commonly affects the lungs and can be fatal if not treated. However, most infected individuals show no disease symptoms. One third of the worlds population is thought to have been infected with TB.

Latest Research and Reviews

Research | 28 July 2017 | open
PyroTyping, a novel pyrosequencing-based assay for Mycobacterium tuberculosis genotyping
- B. Molina-Moya
- , A. Lacoma
- , N. García-Sierra
- , S. Blanco
- , L. Haba
- , S. Samper
- , J. Ruiz-Manzano
- , C. Prat
- , C. Arnold
- & J. Domínguez
Scientific Reports 7, 6777
Reviews | 24 July 2017
Heterogeneity in tuberculosis
Tuberculosis (TB) is a heterogeneous disease: most infections are asymptomatic, but some infected individuals develop active symptomatic disease. This Review describes how features of the host immune response, granulomas and the mycobacteria contribute to the varied outcomes of TB infection.
- Anthony M. Cadena
- , Sarah M. Fortune
- & JoAnne L. Flynn
Nature Reviews Immunology
Research | 25 July 2017 | open
Active Tuberculosis Incidence and Characteristics in Patients Treated with Tumor Necrosis Factor Antagonists According to Latent Tuberculosis Infection
- Eun Hye Lee
- , Young Ae Kang
- , Ah Young Leem
- , Moo Suk Park
- , Young Sam Kim
- , Se Kyu Kim
- , Joon Chang
- & Song Yee Kim
Scientific Reports 7, 6473
Research | 21 July 2017 | open
GeneXpert MTB/RIF assay in the diagnosis of urinary tuberculosis from urine specimens
- Yu Pang
- , Yuanyuan Shang
- , Jie Lu
- , Qian Liang
- , Lingling Dong
- , Yunxu Li
- , Liping Zhao
- , Guanglu Jiang
- & Hairong Huang
Scientific Reports 7, 6181
Research | 18 July 2017 | open
Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions
- Rosalba Perrone
- , Enrico Lavezzo
- , Erika Riello
- , Riccardo Manganelli
- , Giorgio Palù
- , Stefano Toppo
- , Roberta Provvedi
- & Sara N. Richter
Scientific Reports 7, 5743
Research | 18 July 2017 | open
Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells
- John D. Blischak
- , Ludovic Tailleux
- , Marsha Myrthil
- , Cécile Charlois
- , Emmanuel Bergot
- , Aurélien Dinh
- , Gloria Morizot
- , Olivia Chény
- , Cassandre Von Platen
- , Jean-Louis Herrmann
- , Roland Brosch
- , Luis B. Barreiro
- & Yoav Gilad
Scientific Reports 7, 5702

All Research & Reviews

News and Comment

News and Views | 27 June 2017
Host response: Inflammation promotes TB growth
Nitric oxide synthase has long been associated with control of Mycobacterium tuberculosis infection. However, new work reveals that instead of directing an antibacterial killing response, nitric oxide is critical for restraining granulocytic inflammation, which can provide a nutrient-rich niche for increased bacterial growth.
- Christina L. Stallings
Nature Microbiology 2, 17102
Research Highlights | 05 June 2017
Bacterial physiology: An inside job on metabolism
Two new studies reveal how Mycobacterium tuberculosis adapts to environmental stresses that are associated with an intracellular lifestyle.
- Ashley York
Nature Reviews Microbiology 15, 383
News and Views | 25 May 2017
Structural biology: Mycobacterial ESX secrets revealed
Structural analysis of the mycobacterial ESX-5 secretion complex presents an important step towards understanding how the ESX type VII (T7) secretion systems can translocate a multitude of substrates — including virulence factors involved in pathogenesis — across the bacterial cell envelope.
- Tracy Palmer
Nature Microbiology 2, 17074
Research Highlights | 13 April 2017
Anti-Bacterials: Out-SMARting drug resistance
- Alison Farrell
Nature Chemical Biology 13, 451
Correspondence | 09 March 2017
Tuberculosis — drugs in the 2016 development pipeline
- Barbara E. Laughon
- & Carol A. Nacy
Nature Reviews Disease Primers 3, 17015
Research Highlights | 13 February 2017
Bacterial pathogenesis: A deadly chain of events
- Andrea Du Toit
Nature Reviews Microbiology 15, 135

All News & Comment

Tuberculosis

Latest Research and Reviews

PyroTyping, a novel pyrosequencing-based assay for Mycobacterium tuberculosis genotyping

Heterogeneity in tuberculosis

Active Tuberculosis Incidence and Characteristics in Patients Treated with Tumor Necrosis Factor Antagonists According to Latent Tuberculosis Infection

GeneXpert MTB/RIF assay in the diagnosis of urinary tuberculosis from urine specimens

Mapping and characterization of G-quadruplexes in Mycobacterium tuberculosis gene promoter regions

Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells

News and Comment

Host response: Inflammation promotes TB growth

Bacterial physiology: An inside job on metabolism

Structural biology: Mycobacterial ESX secrets revealed

Anti-Bacterials: Out-SMARting drug resistance

Tuberculosis — drugs in the 2016 development pipeline

Bacterial pathogenesis: A deadly chain of events