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TFH CELLS

Selenium saves ferroptotic TFH cells to fortify the germinal center

Nature Immunology volume 22, pages 1074–1076 (2021)Cite this article

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Inhibition of ferroptosis via selenium supplementation promotes the survival of follicular helper T cells, boosting the germinal center and antibody response following vaccination in mice and people.

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Fig. 1: Selenium supplementation boosts TFH cells in mice and humans.

References

  1. Elsner, R. A. & Shlomchik, M. J. Immunity 53, 1136–1150 (2020).

    Article  CAS  Google Scholar 

  2. Vinuesa, C. G., Linterman, M. A., Yu, D. & MacLennan, I. C. M. Annu. Rev. Immunol. 34, 335–368 (2016).

    Article  CAS  Google Scholar 

  3. Linterman, M. A. & Hill, D. L. F1000Res. 5, 88 (2016).

    Article  Google Scholar 

  4. Yao, Y. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00996-0 (2021).

  5. Li, J. et al. Cell Death Dis. 11, 88 (2020).

    Article  Google Scholar 

  6. Allen, C. D. C., Okada, T., Tang, H. L. & Cyster, J. G. Science 315, 528–531 (2007).

    Article  CAS  Google Scholar 

  7. Alim, I. et al. Cell 177, 1262–1279.e25 (2019).

    Article  CAS  Google Scholar 

  8. Jackson, S. H., Devadas, S., Kwon, J., Pinto, L. A. & Williams, M. S. Nat. Immunol. 5, 818–827 (2004).

    Article  CAS  Google Scholar 

  9. Merkenschlager, J. et al. Nature 591, 458–463 (2021).

    Article  CAS  Google Scholar 

  10. Faliti, C. E. et al. J. Exp. Med. 216, 317–336 (2019).

    Article  CAS  Google Scholar 

  11. Stebegg, M. et al. Elife 9, e52473 (2020).

    Article  CAS  Google Scholar 

  12. Hill, D. L. et al. J. Exp. Med. 216, 1857–1873 (2019).

    Article  CAS  Google Scholar 

  13. Nielsen, C. M. et al. Cell Rep. Med. 2, 100207 (2021).

    Article  Google Scholar 

  14. Matsushita, M. et al. J. Exp. Med. 212, 555–568 (2015).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Immunology Programme, Babraham Institute, Cambridge, UK

    Michelle A. Linterman

  2. Department of Immunology and Inflammation, Imperial College London, London, UK

    Alice E. Denton

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  1. Michelle A. Linterman
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  2. Alice E. Denton
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Correspondence to Michelle A. Linterman.

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Linterman, M.A., Denton, A.E. Selenium saves ferroptotic TFH cells to fortify the germinal center. Nat Immunol 22, 1074–1076 (2021). https://doi.org/10.1038/s41590-021-01007-y

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