Ulrich von Andrian recounts how an unexpected experimental result called into question a well-established concept in immunology: the mechanism of immune memory. Follow-up experiments revealed that NK cells can mediate antigen-specific adaptive immune responses.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Morales, A., Eidinger, D. & Bruce, A. W. J. Urol. 116, 180–183 (1976).
Taniguchi, K. et al. Clin. Exp. Immunol. 115, 131–135 (1999).
Ratliff, T. L., Shapiro, A. & Catalona, W. J. Clin. Immunol. Immunopathol. 41, 108–115 (1986).
Redelman-Sidi, G., Glickman, M. S. & Bochner, B. H. Nat. Rev. Urol. 11, 153–162 (2014).
von Andrian, U. H. & Mackay, C. R. N. Engl. J. Med. 343, 1020–1034 (2000).
Asherson, G. L. & Ptak, W. Immunology 15, 405–416 (1968).
Askenase, P. W. Clin. Exp. Immunol. 125, 345–350 (2001).
Elmas, Ö. F., Akdeniz, N., Atasoy, M. & Karadag, A. S. Clin. Dermatol. 38, 176–192 (2020).
Phanuphak, P., Moorhead, J. W. & Claman, H. N. J. Immunol. 112, 849–851 (1974).
O’Leary, J. G., Goodarzi, M., Drayton, D. L. & von Andrian, U. H. Nat. Immunol. 7, 507–516 (2006).
Marchal, G., Seman, M., Milon, G., Truffa-Bachi, P. & Zilberfarb, V. J. Immunol. 129, 954–958 (1982).
Bellavia, A. et al. Int. Arch. Allergy Immunol. 101, 402–407 (1993).
Asherson, G. L., Allwood, G. G. & Mayhew, B. Immunology 25, 485–494 (1973).
Biedermann, T. et al. J. Exp. Med. 192, 1441–1452 (2000).
Jung, D. & Alt, F. W. Cell 116, 299–311 (2004).
Boehncke, W.-H. et al. Exp. Dermatol. 14, 70–80 (2005).
Burnet, F. M. Aust. J. Sci. 20, 67–69 (1957).
Vermijlen, D. et al. J. Leukoc. Biol. 72, 668–676 (2002).
Vermijlen, D. et al. Eur. J. Immunol. 34, 2529–2540 (2004).
Hanke, T. et al. Immunity 11, 67–77 (1999).
Kim, S. et al. Nature 436, 709–713 (2005).
Paust, S. et al. Nat. Immunol. 11, 1127–1135 (2010).
Pancer, Z. et al. Nature 430, 174–180 (2004).
Flajnik, M. F. & Kasahara, M. Immunity 15, 351–362 (2001).
Majewska-Szczepanik, M., Paust, S., von Andrian, U. H., Askenase, P. W. & Szczepanik, M. Immunology 140, 98–110 (2013).
Rouzaire, P. et al. Eur. J. Immunol. 42, 80–88 (2012).
van den Boorn, J. G. et al. Immunity 44, 1406–1421 (2016).
Gillard, G. O. et al. PLoS Pathog. 7, e1002141 (2011); erratum https://doi.org/10.1371/annotation/b29086ef-e08d-444c-8113-18a6dd429a7c (2011).
Habib, S., El Andaloussi, A., Hisham, A. & Ismail, N. PLoS ONE 11, e0153223 (2016).
Sun, J. C., Beilke, J. N. & Lanier, L. L. Nature 457, 557–561 (2009).
Reeves, R. K. et al. Nat. Immunol. 16, 927–932 (2015).
Nikzad, R. et al. Sci. Immunol. 4, eaat8116 (2019).
Foley, B. et al. Blood 119, 2665–2674 (2012).
Milush, J. M. et al. Retrovirology 10, 158 (2013).
Stary, V. et al. Sci. Immunol. 5, eaba6232 (2020).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
von Andrian, U.H. NK cell memory: discovery of a mystery. Nat Immunol 22, 669–671 (2021). https://doi.org/10.1038/s41590-021-00890-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-021-00890-9
This article is cited by
-
Role of the Hematopoietic Stem Cells in Immunological Memory
Current Stem Cell Reports (2022)