Screening of a chemical library identifies a novel ferroptosis inhibitor that directly interferes with the formation of intracellular membrane contacts between the endoplasmic reticulum (ER) and mitochondria (ERMCS), commonly referred to as mitochondria-associated membranes (MAMs).
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References
Zhang, Z. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01512-1 (2024).
Xie, Y., Kang, R., Klionsky, D. J. & Tang, D. Autophagy 19, 2621–2638 (2023).
Kang, M. J. et al. Proc. Natl Acad. Sci. USA 94, 2880–2884 (1997).
Doll, S. et al. Nat. Chem. Biol. 13, 91–98 (2017).
Booth, D. M., Enyedi, B., Geiszt, M., Varnai, P. & Hajnoczky, G. Mol. Cell 63, 240–248 (2016).
Jacob, R. F. & Mason, R. P. J. Biol. Chem. 280, 39380–39387 (2005).
Anastasia, I. et al. Cell Rep. 34, 108873 (2021).
Raturi, A. et al. J. Cell. Biol. 214, 433–444 (2016).
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Chen, J., Makio, T. & Simmen, T. Ironing out the mitochondria. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-023-01509-w
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DOI: https://doi.org/10.1038/s41589-023-01509-w
