The integrated stress response affects cell survival or death under stress conditions, and depends on the activity of the eukaryotic translation initiation factor eIF2B. New research identifies a protein helix that modulates this response by controlling the structural states of eIF2B.
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Kashiwagi, K., Ito, T. Switching on stress. Nat Chem Biol 20, 394–395 (2024). https://doi.org/10.1038/s41589-023-01436-w
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DOI: https://doi.org/10.1038/s41589-023-01436-w