Structure determination

Definition

Structure determination is a procedure by which the three-dimensional atomic coordinates of a molecule or biomolecule are solved using an analytical technique. Many techniques are used in structure determination, most commonly X-ray crystallography, NMR spectroscopy, electron microscopy and molecular modelling.

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Latest Research and Reviews

  • Research |

    Sequence-specific interactions between the Hepatitis B virus pre-genome and the core protein define the nucleocapsid assembly pathway and trigger virus-like particle formation. Cp-RNA contacts may regulate pre-genome organization, facilitating reverse transcription.

    • Nikesh Patel
    • , Simon J. White
    • , Rebecca F. Thompson
    • , Richard Bingham
    • , Eva U. Weiß
    • , Daniel P. Maskell
    • , Adam Zlotnick
    • , Eric C. Dykeman
    • , Roman Tuma
    • , Reidun Twarock
    • , Neil A. Ranson
    •  & Peter G. Stockley
  • Research |

    A new sample-delivery method for serial X-ray crystallography exploits the full repetition rate of the X-ray free-electron laser at the LCLS facility, thus enabling efficient, high-speed data collection to solve the three-dimensional structures of viruses.

    • Philip Roedig
    • , Helen M Ginn
    • , Tim Pakendorf
    • , Geoff Sutton
    • , Karl Harlos
    • , Thomas S Walter
    • , Jan Meyer
    • , Pontus Fischer
    • , Ramona Duman
    • , Ismo Vartiainen
    • , Bernd Reime
    • , Martin Warmer
    • , Aaron S Brewster
    • , Iris D Young
    • , Tara Michels-Clark
    • , Nicholas K Sauter
    • , Abhay Kotecha
    • , James Kelly
    • , David J Rowlands
    • , Marcin Sikorsky
    • , Silke Nelson
    • , Daniel S Damiani
    • , Roberto Alonso-Mori
    • , Jingshan Ren
    • , Elizabeth E Fry
    • , Christian David
    • , David I Stuart
    • , Armin Wagner
    •  & Alke Meents
  • Research | | open

    Phytoplankton and plant plastids have distinct evolutionary origins and membrane organization. Here Flori et al. show that diatom photosynthetic complexes spatially segregate into interconnected subdomains within loose thylakoid stacks enabling fast diffusion of electron carriers and efficient photosynthesis

    • Serena Flori
    • , Pierre-Henri Jouneau
    • , Benjamin Bailleul
    • , Benoit Gallet
    • , Leandro F Estrozi
    • , Christine Moriscot
    • , Olivier Bastien
    • , Simona Eicke
    • , Alexander Schober
    • , Carolina Río Bártulos
    • , Eric Maréchal
    • , Peter G Kroth
    • , Dimitris Petroutsos
    • , Samuel Zeeman
    • , Cécile Breyton
    • , Guy Schoehn
    • , Denis Falconet
    •  & Giovanni Finazzi

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