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GPCR structural biology

Capturing receptor states with glue

Nature Chemical Biology volume 20, pages 6–7 (2024)Cite this article

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A universally effective method has been developed to enable cryo-electron microscopy structural determination of G protein–coupled receptors in various states. This method will accelerate structure-based drug discovery and enhance understanding of the activation mechanism for these receptors.

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Fig. 1: Approaches for enabling cryo-EM structural determination of GPCRs.

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Authors and Affiliations

  1. Center for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA

    Sarah M. Bernhard & Tao Che

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  1. Sarah M. Bernhard
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  2. Tao Che
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Correspondence to Tao Che.

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The authors declare no competing interests.

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Bernhard, S.M., Che, T. Capturing receptor states with glue. Nat Chem Biol 20, 6–7 (2024). https://doi.org/10.1038/s41589-023-01396-1

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