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Immunology

ZEB2 promotes formation of age-related B cells

Nature Reviews Rheumatology volume 20, page 138 (2024)Cite this article

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New research has identified the transcription factor ZEB2 as the mediator of the differentiation of age-associated B cells (ABCs), with therapeutic implications for autoimmune diseases.

ABCs, also known as double-negative DN2 B cells or CD11c+ atypical memory B cells, constitute an effector B cell subset that is associated with ageing, infection and systemic autoimmune disease. “Their protective function in the context of infectious disease and pathogenic roles in autoimmunity and ageing place ABCs as a key therapeutic target in each of these settings,” explains Nan Shen, corresponding author of the Science paper describing the new research.

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Original article

  • Dai, D. et al. The transcription factor ZEB2 drives the formation of age-associated B cells. Science 383, 413–421 (2024)

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  1. Nature Reviews Rheumatology http://www.nature.com/nrrheum/

    Robert Phillips

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  1. Robert Phillips
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Correspondence to Robert Phillips.

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Phillips, R. ZEB2 promotes formation of age-related B cells. Nat Rev Rheumatol 20, 138 (2024). https://doi.org/10.1038/s41584-024-01089-6

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  • DOI: https://doi.org/10.1038/s41584-024-01089-6

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