Stimulator of interferon genes (STING), an important component of the cytosolic DNA sensing pathway, is an attractive therapeutic target for ameliorating interferon-driven systemic inflammation. New findings are shedding light on how STING functions and on a strategy to target STING therapeutically.
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Acknowledgements
Y.J.C. acknowledges the European Research Council (GA 309449 and 786142-E-T1IFNs), ERA-NET Neuron (MR/M501803/1) and a state subsidy managed by the National Research Agency (France) under the “Investments for the Future” programme bearing the reference ANR-10-IAHU-01.
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Uggenti, C., Crow, Y.J. Taking the STING out of inflammation. Nat Rev Rheumatol 14, 508–509 (2018). https://doi.org/10.1038/s41584-018-0071-z
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DOI: https://doi.org/10.1038/s41584-018-0071-z
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